Novel Blood RNA System

A new blood RNA system is for the collection, storage, transport of blood, the stabilization of intracellular RNA in a closed tube, and the subsequent isolation and purification of intracellular RNA from whole blood for reverse transcription polymerase chain reaction (RT-PCR) used in molecular diagnostic testing.

The PaxGene system was developed by PreAnalytix GmbH (Hombrechtikon, Switzerland). The system has been cleared by the U.S. Food and Drug Administration (FDA) and has received the CE Mark, while PreAnalytix has received ISO 9001 certification.

The PaxGene blood RNA system is an enabling technology that consolidates and integrates the key steps of whole blood collection, nucleic acid stabilization, and RNA purification. By minimizing the unpredictability associated with RNA processing, the system provides enhanced accuracy, greater efficiencies, and reduced costs of intracellular RNA analysis. Intracellular RNA is a key component of numerous diagnostic products. The PaxGene system comprises a blood collection tube and a nucleic acid processing kit. The collection tube contains a reagent that stabilizes intracellular RNA for three days at room temperature and up to six months at -20oC.

"The PaxGene Blood RNA system has significantly enhanced our ability to detect messenger RNA,” observed Daniel J. O'Shannessy, Ph.D., COO of Targeted Diagnostics & Therapeutics, Inc. (West Chester, PA, USA). "The stability of the RNA afforded by the PaxGene system allows us to received blood samples from across the United States and internationally into our laboratory in Pennsylvania.”




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PreAnalytix