Plant-Derived Culture Media

A new plant-derived recombinant growth factor for cell culture media promotes productivity and safety.

Called Lacromin, the growth factor is a recombinant human lactoferrin derived from plants, which outperforms transferrin, a common animal-derived growth factor. Lacromin is the product of Ventria Bioscience (Sacramento, CA, USA).

Lacromin is a strong growth factor that has promoted cell growth in many cell lines, including Chinese hamster ovary (CHO) cells and mouse hybridoma cells. The growth factor also promotes higher cell density and reduces cell doubling time when compared to transferrin. Since Lacromin is derived from plants, it is free of any viral or prion containment risks. In hybriderma cells, Lacromin increased IgG productivity by 50% compared to transferrin and by 6% compared to fetal bovine serum (FBS).

"We are very encouraged by the positive results we have generated on Lacromin,” said Ning Huang, vice president of research and development, Ventria Bioscience. Mr. Huang introduced Lacromin at the Raw Materials and Disposable Process Systems for Mammalian Cell Culture Products Conference in Kansas City (MO, USA) in July 2005. "At the conference today, I presented results showing Lacromin significantly increased the productivity of antibody production when compared with animal-derived transferrin.”

The company will market Lacromin to companies seeking a serum-free and animal component-free cell culture media source.




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Ventria Bioscience