Microscope-Based Screening Station

A screening station for life science combines the modularity and flexibility of a microscope-based set-up with the automation, throughput, reliability, and reproducibility demands of screening applications. The system is suitable for standard assays and assay development.

The modular optical bench design of the Olympus (Hamburg, Germany) Scan^R screening station for life science, allows users to adapt the system to specific applications of research and development (R&D) labs and to multi-user environments. Scan^R can handle different sample formats, including multi-well plates, slides, and custom-built arrays. The analysis module for biologic functioning assays enables assay development and high-content screening. The comprehensive image analysis and advanced data evaluation tools make possible a wide range of assays including gene expression, translocation, and cell lysis.

Fixed and live cells are handled with ease, tracking changes with time and enabling users to see the end-point of an assay. The Scan^R incorporates software and hardware modules controlled by an easy-to-use interface. Providing precise control of the microscope, focus, image display, as well as dedicated file and folder storage, the system produces six-dimensional images. A comprehensive set of cytometry-orientated modules automatically analyzes these images, providing full image processing, object and sub-object detection, parameter calculation, as well as sophisticated gating and analysis logarithms. Additional components can be added to scan^R to extend the functionality of the screening station.



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