Assay for Detecting West Nile Virus in Donated Blood

A nucleic acid assay for detecting West Nile virus in donated blood can simultaneously detect West Nile Virus (including the Kunjin and New York strains), St. Louis encephalitis virus, Japanese encephalitis virus, and Murray Valley encephalitis virus.

The polymerase chain reaction (PCR)-based assay, called TaqScreen, is designed to prevent the spread of deadly viruses through the transfusion of blood and blood products. In September 2002, the US Centers for Disease Control and Prevention (CDC, Atlanta, GA, USA) called on diagnostic industry to have a blood screening test for West Nile virus ready for the 2003 mosquito season because the incidence of infection is expected to increase in 2003. The CDC has indicated that a small number of West Nile virus cases had likely spread through blood transfusions and tissue donations in 2002.

"Three features distinguish Roche's West Nile virus test,” explained James Gallarda, director of blood screening development at Roche Molecular Diagnostics. "First, its broader coverage, made possible by the detailed genetic research our scientists conducted on the Japanese encephalitis group of viruses. Second, total automation, an important feature for blood banks working hard to ensure the safest possible blood supplies. And third, genetic extraction, which adds further value by allowing us to respond more quickly should our customers need to screen for other emerging pathogens.”




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