Stem Cell Spray Technology Could Help Treat Severe Wounds

A quick-healing spray system uses a patient’s own stem cells as an alternative to conventional skin graft surgery, which can be painful, prone to complications, and slow-to-heal.

The CellMist System is an innovative investigational treatment for processing and spraying a patient’s own stem cells onto wounds for rapid healing. The system is comprised of the CellMist Solution, a liquid suspension containing a patient’s own stem cells which are isolated from a small sample of their skin, using a patented extraction process. The second component of the system is the SkinGun device, which gently sprays the CellMist Solution on to a wound site for rapid healing. Once sprayed onto the wound site, the patient’s stem cells go to work, naturally and rapidly regenerating damaged skin.


Patented SkinGun technology results in 200-times more droplets formed than in conventional syringe deposition; for example, in an 8 cm diameter surface area, the SkinGun can deliver more than 20,000 evenly distributed droplets, versus only 91 droplets by conventional needle and syringe methods. The CellMist System is designed to replace traditional skin grafts, requiring only a postage stamp-sized sample of donor skin, which can be processed within 90 minutes of arriving in an emergency room. The CellMist System is under development by RenovaCare (New York, NY, USA).

“The prospect of spraying a patient’s own stem cells onto burns and wounds to create rapid, scar-free healing is a promising alternative to today’s painful and disfiguring skin grafting procedures,” said Thomas Bold, President and CEO of RenovaCare. “For patients, we are working towards natural, rapid healing where their new skin can look and function as well as it once did. For surgeons, it’s a relief to no longer have to remove vast sheets of healthy skin and surgically stitch it to wound sites.”

Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin (mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc). They have been successfully used for many years to treat leukemia and related bone cancers through bone marrow transplants. Adult somatic stem cells can now be artificially grown and differentiated into specialized cell types with characteristics consistent with cells of various tissues.

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