Miniaturized Implantable Multi-Sensors Device to Monitor Vessels Health

Researchers have embarked on a project to develop a multi-sensing device that can be implanted into blood vessels like peripheral veins or arteries to monitor a range of bodily parameters and overall health status. This implantable microsensor system, designed for patients with cardiovascular diseases, aims to provide a versatile platform that can assess both hemodynamic and biochemical parameters.

The EU-funded project IV-Lab (an acronym for In-vessel implantable smart sensing device for personalized medicine) coordinated by the Italian Institute of Technology (IIT, Genoa, Italy) is developing the miniaturized sensing device for continuous monitoring of different parameters related to blood vessel health and patient well-being. Unlike existing devices, this new sensor will integrate multiple sensors within a small platform, only 1-2 cm long and 2-4 mm in diameter. Advanced fabrication techniques are critical to this integration, allowing for the microscale fabrication of sensors and their subsequent transfer, assembly, and connection onto a support frame. These sensors will measure parameters such as blood pressure, vessel deformation, oximetry, hematocrit, and specific cardiovascular biomarkers. The key aim is to equip physicians with essential data remotely to enable quick and early interventions for preventing heart failures.

Image: The multi-sensing device can be implanted into blood vessels to help physicians deliver timely treatment (Photo courtesy of IIT)

The system, once implanted, will connect to an external data collection and communication system that can operate through standard wireless technology or even a smartphone for asynchronous on-demand monitoring. Its tiny size is designed to be easily implanted via catheterization in a peripheral vein. Part of the project is devoted to evaluating the performance of the developed prototype through laboratory testing, with a strong emphasis on biocompatibility and other medical considerations. Going forward, the system could potentially monitor disease progression and outcomes, thus enabling doctors to provide timely and personalized treatments. The researchers envision a future where the implanted micro-sensor system is fully integrated into cloud networks, allowing artificial intelligence software to analyze data from multiple sensors. This integration would alert medical professionals to any abnormal readings, enabling them to initiate preventive protocols for various diseases effectively.

“The device will find important applications in the field of cardiovascular disease, in particular in those patients in which the detection of hemodynamic behavior and specific biomarkers could reduce the rehospitalization and mortality, such as heart failure or coronary restenosis after stent implantation,” said Virgilio Mattoli, IIT researcher and IV-LAB coordinator.

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Italian Institute of Technology