Thrombolytic Drug Delivery Device Dissolves Blood Clots
By HospiMedica International staff writers Posted on 21 Jul 2014 |

Image: The Trellis peripheral infusion system (Photo courtesy of Covidien).
A redesigned peripheral infusion system enables focused treatment of blood clots to avoid potential post-thrombotic syndrome (PTS).
The updated Trellis peripheral infusion system is a pharmacomechanical thrombolysis device that provides a way for physicians to dissolve blood clots resulting from acute deep vein thrombosis (DVT), and before they advance to PTS. The system is comprised of an over-the-wire catheter with two occlusive balloons to close off the treatment area and block drug release to other areas of the body; an infusion zone to deliver the lytic drug; and an oscillation drive unit (ODU) with an integrated dispersion wire to distribute the drug.
The updated system features enhanced drug delivery, increased amplitude of the ODU, and a larger aspiration window than the previous version, which allows for better removal of the drug and the dissolved clot. The system is available in a 6 French catheter size for vessels 3–10 mm in diameter, and an 8 French version for vessels 5–16 mm in diameter. The Trellis peripheral infusion system is a product of Covidien (Dublin, Ireland), and can be used for both arterial and venous peripheral usage.
“Covidien is committed to providing clinicians and patients with advanced technology that is clinically relevant and demonstrates economic value. Our clinical data has demonstrated that the Trellis system’s targeted lytic delivery may reduce the risk of bleeding complications normally associated with systemic thrombolytic infusion,” said Mark Turco, MD, chief medical officer of vascular therapies at Covidien. “Furthermore, intervening in patients with DVT may help improve long-term outcomes in a population that can suffer significant complications if left untreated.”
PTS is a long-term effect of DVT (a condition where a clot develops in one of the body’s deep veins above the knee), and develops when a DVT interferes with the blood flow returning from the leg back to the heart. It can cause lower leg pain and swelling by causing damage to the valves in the veins that normally stop blood from flowing backwards down the leg. PTS occurs in almost half of patients within two years after DVT, and up to 33% of patients with PTS develop ulcers and skin deterioration.
Related Links:
Covidien
The updated Trellis peripheral infusion system is a pharmacomechanical thrombolysis device that provides a way for physicians to dissolve blood clots resulting from acute deep vein thrombosis (DVT), and before they advance to PTS. The system is comprised of an over-the-wire catheter with two occlusive balloons to close off the treatment area and block drug release to other areas of the body; an infusion zone to deliver the lytic drug; and an oscillation drive unit (ODU) with an integrated dispersion wire to distribute the drug.
The updated system features enhanced drug delivery, increased amplitude of the ODU, and a larger aspiration window than the previous version, which allows for better removal of the drug and the dissolved clot. The system is available in a 6 French catheter size for vessels 3–10 mm in diameter, and an 8 French version for vessels 5–16 mm in diameter. The Trellis peripheral infusion system is a product of Covidien (Dublin, Ireland), and can be used for both arterial and venous peripheral usage.
“Covidien is committed to providing clinicians and patients with advanced technology that is clinically relevant and demonstrates economic value. Our clinical data has demonstrated that the Trellis system’s targeted lytic delivery may reduce the risk of bleeding complications normally associated with systemic thrombolytic infusion,” said Mark Turco, MD, chief medical officer of vascular therapies at Covidien. “Furthermore, intervening in patients with DVT may help improve long-term outcomes in a population that can suffer significant complications if left untreated.”
PTS is a long-term effect of DVT (a condition where a clot develops in one of the body’s deep veins above the knee), and develops when a DVT interferes with the blood flow returning from the leg back to the heart. It can cause lower leg pain and swelling by causing damage to the valves in the veins that normally stop blood from flowing backwards down the leg. PTS occurs in almost half of patients within two years after DVT, and up to 33% of patients with PTS develop ulcers and skin deterioration.
Related Links:
Covidien
Latest Critical Care News
- Novel Coating Significantly Extends Longevity of Implantable Biosensors
- Nanogel-Based Drug Delivery Technology to Improve UTI Treatment
- New IV Pole Improves Safety and Ease of Administering IV Medications at Hospital Bedside
- Battery-Powered Wearable Device Monitors Joint Pain
- Wireless Pacifier Monitors Vitals of NICU Babies Without Need for Painful Blood Draws
- Breakthrough Sensor Technology Tracks Stroke After Effects
- New Study Demonstrates AI-Assisted Detection of Reduced Ejection Fraction
- Novel 3D Adipose Tissue Bioprinting Method to Find Applications in Regenerative Medicine
- Miniaturized Pacemaker for Newborns Found Safe and Effective for Up to Two Years
- World’s First 3D Neural Electrode Uses Soft Actuation Technology to Avoid Nerve Damage
- Smartwatch Algorithm Detects Cardiac Arrest
- Blood-Brain Barrier “Organ Chip” Treats Brain Tumors Unreachable by Chemotherapy
- AI Model Could Use ECG Tests to Detect Premature Aging and Cognitive Decline
- World-First Technology Uses Real-Time ECG Signal Analysis for Accurate CVAD Placement
- AI Outperforms Humans at Analyzing Long-Term ECG Recordings
- Smart Sensor Enables Precise, Self-Powered Tracking of Healing Wounds
Channels
Artificial Intelligence
view channel
Innovative Risk Score Predicts Heart Attack or Stroke in Kidney Transplant Candidates
Heart researchers have utilized an innovative risk assessment score to accurately predict whether patients being evaluated for kidney transplants are at risk for future major cardiac events, such as a... Read more
AI Algorithm Detects Early-Stage Metabolic-Associated Steatotic Liver Disease Using EHRs
Liver disease, which is treatable when detected early, often goes unnoticed until it reaches advanced stages. Metabolic-associated steatotic liver disease (MASLD), the most prevalent form of liver disease,... Read moreSurgical Techniques
view channel
Easy-To-Apply Gel Could Prevent Formation of Post-Surgical Abdominal Adhesions
Surgical adhesions are a frequent and often life-threatening complication following open or laparoscopic abdominal surgery. These adhesions develop in the weeks following surgery as the body heals.... Read more
Groundbreaking Leadless Pacemaker to Prevent Invasive Surgeries for Children
Leadless pacemakers marked a significant advancement in cardiac care, primarily because traditional pacemakers are dependent on leads, which are prone to breakage over time. Currently, two FDA-approved... Read morePatient Care
view channel
Portable Biosensor Platform to Reduce Hospital-Acquired Infections
Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more
First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds
Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more
Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization
An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more
Game-Changing Innovation in Surgical Instrument Sterilization Significantly Improves OR Throughput
A groundbreaking innovation enables hospitals to significantly improve instrument processing time and throughput in operating rooms (ORs) and sterile processing departments. Turbett Surgical, Inc.... Read moreHealth IT
view channel
Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors
The future of medicine is likely to focus on the personalization of healthcare—understanding exactly what an individual requires and delivering the appropriate combination of nutrients, metabolites, and... Read more
Smartwatches Could Detect Congestive Heart Failure
Diagnosing congestive heart failure (CHF) typically requires expensive and time-consuming imaging techniques like echocardiography, also known as cardiac ultrasound. Previously, detecting CHF by analyzing... Read morePoint of Care
view channel
Handheld, Sound-Based Diagnostic System Delivers Bedside Blood Test Results in An Hour
Patients who go to a doctor for a blood test often have to contend with a needle and syringe, followed by a long wait—sometimes hours or even days—for lab results. Scientists have been working hard to... Read more
Smartphone-Enabled, Paper-Based Quantitative Diagnostic Platform Transforms POC Testing
Point-of-care diagnostics are crucial for public health, offering rapid, on-site testing that enables prompt diagnosis and treatment. This is especially valuable in remote or underserved regions where... Read moreBusiness
view channel
Becton Dickinson to Spin Out Biosciences and Diagnostic Solutions Business
Becton, Dickinson and Company (BD, Franklin Lakes, NJ, USA), has announced that its board of directors has unanimously authorized BD management to pursue a plan to separate BD's Biosciences and Diagnostic... Read more