Hormone Replacement Therapy Preserves Joint Implants
|
By HospiMedica International staff writers Posted on 23 Feb 2015 |
|
A new study reveals that hormone replacement therapy (HRT) is associated with an almost 40% decrease in the rate of revision surgery for hip and knee implants in women.
Researchers at the University of Oxford (United Kingdom), Universitat Autònoma de Barcelona (UAB; Spain), and other institutions conducted a study of 24,733 women who underwent primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) to examine if HRT could reduce osteolysis and subsequent prosthesis loosening, the most common cause for revision surgery. The researchers explored associations with HRT use for over a year, adherence, and cumulative use and revision risk.
The results showed that the hazard ratio for implant failure fell to 0.62 after six months among HRT users. The risk reduction fell even further, reaching 0.48 for those who continued on HRT for at least a year. The results also showed that higher adherence and therapy duration were associated with further reductions in revision rates, but that preoperative HRT appeared unrelated to implant survival. The study was published in the March 2015 issue of Annals of the Rheumatic Diseases.
“Animal studies have suggested that estrogen deficiency exerts a negative influence on bone tissue around knee implants, while HRT minimizes periprosthetic bone loss and improves bone ingrowth around the implant,” concluded lead author Nigel Arden, MD, of the University of Oxford, and colleagues. “The findings that significant reductions in revision risk were seen among HRT users are encouraging for the research of antiresorptive agents that might improve outcomes following total joint replacement surgery in the future.”
The most common reason for joint replacement failure in the first year post implantation is due to aseptic loosening, which can result from osteolysis in the surrounding bone. While the mechanisms underlying loosening are still obscure, it is widely accepted that periprosthetic bone loss secondary to chronic inflammation and osteoclastic activity is the main pathway.
Related Links:
University of Oxford
Universitat Autònoma de Barcelona
Researchers at the University of Oxford (United Kingdom), Universitat Autònoma de Barcelona (UAB; Spain), and other institutions conducted a study of 24,733 women who underwent primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) to examine if HRT could reduce osteolysis and subsequent prosthesis loosening, the most common cause for revision surgery. The researchers explored associations with HRT use for over a year, adherence, and cumulative use and revision risk.
The results showed that the hazard ratio for implant failure fell to 0.62 after six months among HRT users. The risk reduction fell even further, reaching 0.48 for those who continued on HRT for at least a year. The results also showed that higher adherence and therapy duration were associated with further reductions in revision rates, but that preoperative HRT appeared unrelated to implant survival. The study was published in the March 2015 issue of Annals of the Rheumatic Diseases.
“Animal studies have suggested that estrogen deficiency exerts a negative influence on bone tissue around knee implants, while HRT minimizes periprosthetic bone loss and improves bone ingrowth around the implant,” concluded lead author Nigel Arden, MD, of the University of Oxford, and colleagues. “The findings that significant reductions in revision risk were seen among HRT users are encouraging for the research of antiresorptive agents that might improve outcomes following total joint replacement surgery in the future.”
The most common reason for joint replacement failure in the first year post implantation is due to aseptic loosening, which can result from osteolysis in the surrounding bone. While the mechanisms underlying loosening are still obscure, it is widely accepted that periprosthetic bone loss secondary to chronic inflammation and osteoclastic activity is the main pathway.
Related Links:
University of Oxford
Universitat Autònoma de Barcelona
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Monitor/Defibrillator
Zenix
Resorbable Bovine Collagen Membrane
GenDerm
Latest Surgical Techniques News
- New Access Platform Aims to Expand Minimally Invasive Spine Surgery
- Dual-Mobility Hip Implant Cuts Postoperative Dislocations
- Low-Frequency Ultrasound Selectively Targets Oral Cancer Cells
- Aortic Arch Remodeling Device Improves Type I Dissection Repair
- Intravesical CAR T Therapy Shows Promise for Bladder Cancer Treatment
- AI Tool Predicts Surgical Scheduling Gaps to Improve OR Utilization
- Living Valve Surgery Delivers Durable Outcomes for Aortic Valve Disease
- Innovative Central Line System Reduces Steps and Procedure Time
- Minimally Invasive Embolization Procedure Reduces Knee Osteoarthritis Pain
- Rapid AI OCT System Detects Malignant Liver Tissue Intraoperatively
- Automated EMR-Based Tool Detects Immune-Related Colitis in Immunotherapy Patients
- Personalized Cartilage Graft Offers New Option for Infants with Severe Airway Narrowing
- Minimally Invasive Procedure Reduces Knee Osteoarthritis Pain
- Computer-Assisted Vacuum Thrombectomy System Cleared for Stroke Care
- Near-Infrared Exoscope Enables Real-Time Perfusion Assessment and Lymphatic Mapping in Open Surgery
- Expandable Lumbar Fusion System Gains FDA 510(k) Clearance
Channels
Artificial Intelligence
view channel
AI Tool Predicts Chronic Kidney Disease Risk in Diabetes
Chronic kidney disease is a common and serious complication of type 2 diabetes and often progresses without obvious early symptoms, increasing morbidity and straining health systems. Many risk models were... Read more
AI Trends Report Guides Responsible, Effective Healthcare Deployment
Hospitals are under growing pressure to adopt artificial intelligence tools that improve safety, efficiency, and continuity of care without compromising quality. At the same time, clinicians need clearer... Read more
Critical Care
view channel
FDA Breakthrough Device Targets Brain Hemorrhage Complications
Subarachnoid hemorrhage, bleeding into the space around the brain most often caused by a ruptured aneurysm, frequently leads to cerebral vasospasm during intensive care. This secondary narrowing of blood... Read more
ECG-Based Screening Framework Aims to Standardize Cardiac Evaluation in Military Personnel
Sudden cardiac death, the unexpected loss of heart function, can occur during intense exertion and remains a concern in physically demanding occupations. Military personnel face additional environmental... Read more
Patient Care
view channel
AI Avatar Doctor Improves Patient Understanding Before Radiotherapy
Radiation oncology consultations require patients to grasp complex concepts quickly, yet anxiety and information overload often undermine understanding and informed consent. Poor comprehension can also... Read more
Wearable Sleep Data Predict Adherence to Pulmonary Rehabilitation
Chronic obstructive pulmonary disease (COPD) is a long-term lung disorder that makes breathing difficult and often disturbs sleep, reducing energy for daily activities. Limited engagement in pulmonary... Read more
Health IT
view channel
Digital Heart Model Supports Targeted Ablation in Atrial Fibrillation
Atrial fibrillation is an erratic, quivering heartbeat and a leading cause of stroke. Catheter ablation is widely used to interrupt arrhythmogenic tissue, yet many patients—especially with persistent ... Read more
AI Framework Helps Clinicians Create Trustworthy Risk Prediction Tools
Artificial intelligence (AI) is increasingly used to estimate risks for conditions such as sepsis, heart disease, and cancer, yet many models remain difficult for clinicians to interpret or trust.... Read more
Point of Care
view channel
New Brain Ultrasound Platform Enables Bedside Postoperative Imaging
Transporting postoperative patients for CT or MRI can create operational burdens, delays, and disruptions in care. Bedside visualization may help reduce transport demands, lower radiation exposure, and... Read more
Handheld Ultrasound Expands Point-of-Care Imaging Access in Brazil
Rapid access to diagnostic imaging is essential across hospitals, emergency departments, clinics, and municipal health systems, but large markets still face uneven availability, particularly in rural regions.... Read more
Business
view channel
Danaher Completes Acquisition of Masimo to Expand Patient Monitoring Capabilities
Danaher Corporation (Washington, DC, USA) has completed its acquisition of Masimo Corporation (Irvine, CA, USA), a specialty diagnostics provider known for pulse oximetry and advanced patient monitoring... Read more
