Hormone Replacement Therapy Preserves Joint Implants
|
By HospiMedica International staff writers Posted on 23 Feb 2015 |
|
A new study reveals that hormone replacement therapy (HRT) is associated with an almost 40% decrease in the rate of revision surgery for hip and knee implants in women.
Researchers at the University of Oxford (United Kingdom), Universitat Autònoma de Barcelona (UAB; Spain), and other institutions conducted a study of 24,733 women who underwent primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) to examine if HRT could reduce osteolysis and subsequent prosthesis loosening, the most common cause for revision surgery. The researchers explored associations with HRT use for over a year, adherence, and cumulative use and revision risk.
The results showed that the hazard ratio for implant failure fell to 0.62 after six months among HRT users. The risk reduction fell even further, reaching 0.48 for those who continued on HRT for at least a year. The results also showed that higher adherence and therapy duration were associated with further reductions in revision rates, but that preoperative HRT appeared unrelated to implant survival. The study was published in the March 2015 issue of Annals of the Rheumatic Diseases.
“Animal studies have suggested that estrogen deficiency exerts a negative influence on bone tissue around knee implants, while HRT minimizes periprosthetic bone loss and improves bone ingrowth around the implant,” concluded lead author Nigel Arden, MD, of the University of Oxford, and colleagues. “The findings that significant reductions in revision risk were seen among HRT users are encouraging for the research of antiresorptive agents that might improve outcomes following total joint replacement surgery in the future.”
The most common reason for joint replacement failure in the first year post implantation is due to aseptic loosening, which can result from osteolysis in the surrounding bone. While the mechanisms underlying loosening are still obscure, it is widely accepted that periprosthetic bone loss secondary to chronic inflammation and osteoclastic activity is the main pathway.
Related Links:
University of Oxford
Universitat Autònoma de Barcelona
Researchers at the University of Oxford (United Kingdom), Universitat Autònoma de Barcelona (UAB; Spain), and other institutions conducted a study of 24,733 women who underwent primary total knee arthroplasty (TKA) or total hip arthroplasty (THA) to examine if HRT could reduce osteolysis and subsequent prosthesis loosening, the most common cause for revision surgery. The researchers explored associations with HRT use for over a year, adherence, and cumulative use and revision risk.
The results showed that the hazard ratio for implant failure fell to 0.62 after six months among HRT users. The risk reduction fell even further, reaching 0.48 for those who continued on HRT for at least a year. The results also showed that higher adherence and therapy duration were associated with further reductions in revision rates, but that preoperative HRT appeared unrelated to implant survival. The study was published in the March 2015 issue of Annals of the Rheumatic Diseases.
“Animal studies have suggested that estrogen deficiency exerts a negative influence on bone tissue around knee implants, while HRT minimizes periprosthetic bone loss and improves bone ingrowth around the implant,” concluded lead author Nigel Arden, MD, of the University of Oxford, and colleagues. “The findings that significant reductions in revision risk were seen among HRT users are encouraging for the research of antiresorptive agents that might improve outcomes following total joint replacement surgery in the future.”
The most common reason for joint replacement failure in the first year post implantation is due to aseptic loosening, which can result from osteolysis in the surrounding bone. While the mechanisms underlying loosening are still obscure, it is widely accepted that periprosthetic bone loss secondary to chronic inflammation and osteoclastic activity is the main pathway.
Related Links:
University of Oxford
Universitat Autònoma de Barcelona
Gold Member
Neonatal Heel Incision Device
Tenderfoot
Hybrid Arch Device
Neo EDE
Monitor/Defibrillator
Zenix
Latest Surgical Techniques News
- New Implant Provides Sustained Localized Therapy for Ovarian Cancer
- Combined Phage and Microbiota Therapy May Reduce Recurrent Urinary Tract Infections
- New AR Technology Provides Real-Time Guidance During ACL Surgery
- New Technique Rapidly Produces Patient-Specific Vascular Grafts During Surgery
- Next-Generation Total Artificial Heart System to Be Presented at IEEE EMBC 2026
- AI Analyzes Surgical Movements to Improve Prostatectomy Outcomes
- Navigation-Compatible Instruments Improve Precision in Lumbar Facet Fusion
- Reusable Pulse Oximetry Sensor Improves Accuracy Across Skin Tones
- Photostable NIR Dye Sustains Intraoperative Imaging in Cancer Surgery
- Single Robotic Platform Supports Three Minimally Invasive Approaches
- Implantable Neural Interface Undergoes First Real-World Surgical Validation
- Robot-Guided Surgery Treats Multiple Deep Brain Abscesses in Single Session
- AI Surgical Platform Enables Real-Time Intraoperative Decision Support
- AI-Guided Arterial Mapping Improves Brain Tumor Drug Delivery
- Implanted Nerve Stimulation May Improve Health Outcomes in Sleep Apnea
- Focused Ultrasound System Gains CE Mark for Liver Tumor Treatment
Channels
Artificial Intelligence
view channel
Collaborative AI System Improves Medical Diagnostic Accuracy
Hospitals face a persistent trade-off when deploying artificial intelligence for diagnosis. Broad “generalist” models handle many tasks but often lack disease-specific precision. Narrow “specialist” models... Read more
AI-Powered Brain-Body Interface Supports Movement and Sensation Recovery
Neurological injuries such as stroke and spinal cord trauma frequently leave patients with profound motor and sensory deficits that limit independence. Rehabilitation may restore some movement, but recovery... Read more
Critical Care
view channel
Wearable Sweat Test Simplifies Cystic Fibrosis Diagnosis
Cystic fibrosis is a genetic disease that disrupts digestion and breathing. Diagnosis depends on sweat chloride testing that is typically limited to accredited centers and specialized laboratories.... Read more
New Risk Calculator Identifies Heart Disease Earlier in Postpartum Women
Cardiovascular disease in women often goes unrecognized until midlife, and standard risk calculators were built for older populations. Complications during pregnancy are linked to later heart disease,... Read more
Patient Care
view channel
AI Avatar Doctor Improves Patient Understanding Before Radiotherapy
Radiation oncology consultations require patients to grasp complex concepts quickly, yet anxiety and information overload often undermine understanding and informed consent. Poor comprehension can also... Read more
Wearable Sleep Data Predict Adherence to Pulmonary Rehabilitation
Chronic obstructive pulmonary disease (COPD) is a long-term lung disorder that makes breathing difficult and often disturbs sleep, reducing energy for daily activities. Limited engagement in pulmonary... Read more
Medical Imaging
view channel
MRI-Guided Ultrasound Method Advances Targeted Treatment of Gliomas
Gliomas, the most common primary brain tumors in adults, include glioblastoma, the deadliest form of brain cancer. Drug delivery is hampered by the brain’s blood-brain barrier, limiting treatment efficacy... Read more
AI Accelerates Individualized Dosimetry for Prostate Cancer Treatment
Radiopharmaceutical therapy is an injected cancer treatment that delivers radiation through the body while selectively targeting tumors. In prostate cancer, current dosing remains largely uniform despite... Read more
Health IT
view channel
Short Digital Training Program Improves Motor Function in Parkinson’s Disease
Parkinson's disease causes motor symptoms that interfere with movement and daily activities. Drug treatment is standard care, yet additional approaches are needed to target motor control.... Read more
New Cloud Platform Streamlines Capsule Endoscopy Workflow and Reporting
Capsule endoscopy programs depend on coordinated acquisition, review, and reporting to support gastrointestinal services. Managing these activities across practices and health systems requires reliable... Read more
Point of Care
view channel
Rapid Onsite Testing Reduces Emergency Department Transfers in Long-Term Care
Respiratory infections in long-term care residents frequently trigger emergency department transfers that strain hospital capacity and expose frail patients to additional risks. Turnaround delays from... Read more
New Brain Ultrasound Platform Enables Bedside Postoperative Imaging
Transporting postoperative patients for CT or MRI can create operational burdens, delays, and disruptions in care. Bedside visualization may help reduce transport demands, lower radiation exposure, and... Read more
Business
view channel
AI Software Combines Nodule Detection and Diagnosis for Lung Cancer Screening
Lung cancer remains the leading cause of cancer mortality, and screening programs rely on computed tomography to identify disease earlier when curative treatment is more likely. High patient volumes and... Read more
