Magnetic Kyphoplasty Helps Spinal Fractures Heal
|
By HospiMedica International staff writers Posted on 08 Aug 2018 |
|
Image: A new study claims magnetic bone cement can be used to guide drugs to VCFs (Photo courtesy of UIC).
Adding magnetic nanoparticles (MNPs) to surgical cement could help surgeons approximate hard to reach spinal fractures, claims a new study.
The novel magnetically-guided drug delivery system, developed by researchers at the University of Illinois in Chicago (UIC, USA), is based on modified kyphoplasty cement that incorporates MNPs, which act as both a guidance stimulus and a localizer for treating vertical compression fractures (VCFs). To test the efficacy of the system, a porcine kyphoplasty model involving cannulated pedicle needles placed into the thoracic vertebra was used. Following inflatable bone tamp expansion, the magnetic bone cement was injected to the vertebral body.
The second stage involved injection of MNPs intravenously, with subsequent histological and qualitative analysis of harvested tissues. The results showed successful placement of magnetic bone cement into the vertebral body and enhanced accumulation of MNPs to the regions that underwent initial injection of magnetic bone cement during the thoracic kyphoplasty procedure. According to the researchers, the technique could also be used to treat spinal column tumors by binding chemotherapy drugs to the MNPs. The study was published on July 27, 2018, in PLOS One.
“By modifying the kyphoplasty bone cement, we can both stabilize the spinal column and provide a targeted drug delivery system,” said co-lead author third-year medical student Steven Denyer, of the UIC College of Medicine. “This is a very promising technology as it has the potential to become a surgical option for patients with primary spinal column tumors or tumors that metastasize to the spinal column.”
VCFs caused by metastatic malignancies or osteoporosis are devastating injuries with debilitating outcomes for patients. Minimally invasive kyphoplasty is a common procedure used for symptomatic amelioration, but it fails to treat the underlying etiologies of VCFs. Cancer patients are often left with spinal column tumors that are very hard to reach with conventional chemotherapy, which has to cross the blood-brain barrier (BBB) when delivered intravenously.
Related Links:
University of Illinois in Chicago
The novel magnetically-guided drug delivery system, developed by researchers at the University of Illinois in Chicago (UIC, USA), is based on modified kyphoplasty cement that incorporates MNPs, which act as both a guidance stimulus and a localizer for treating vertical compression fractures (VCFs). To test the efficacy of the system, a porcine kyphoplasty model involving cannulated pedicle needles placed into the thoracic vertebra was used. Following inflatable bone tamp expansion, the magnetic bone cement was injected to the vertebral body.
The second stage involved injection of MNPs intravenously, with subsequent histological and qualitative analysis of harvested tissues. The results showed successful placement of magnetic bone cement into the vertebral body and enhanced accumulation of MNPs to the regions that underwent initial injection of magnetic bone cement during the thoracic kyphoplasty procedure. According to the researchers, the technique could also be used to treat spinal column tumors by binding chemotherapy drugs to the MNPs. The study was published on July 27, 2018, in PLOS One.
“By modifying the kyphoplasty bone cement, we can both stabilize the spinal column and provide a targeted drug delivery system,” said co-lead author third-year medical student Steven Denyer, of the UIC College of Medicine. “This is a very promising technology as it has the potential to become a surgical option for patients with primary spinal column tumors or tumors that metastasize to the spinal column.”
VCFs caused by metastatic malignancies or osteoporosis are devastating injuries with debilitating outcomes for patients. Minimally invasive kyphoplasty is a common procedure used for symptomatic amelioration, but it fails to treat the underlying etiologies of VCFs. Cancer patients are often left with spinal column tumors that are very hard to reach with conventional chemotherapy, which has to cross the blood-brain barrier (BBB) when delivered intravenously.
Related Links:
University of Illinois in Chicago
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
Silver Member
X-Ray QA Device
Accu-Gold+ Touch Pro
Half Apron
Demi
Latest Surgical Techniques News
- Minimally Invasive Endoscopic Surgery Improves Severe Stroke Outcomes
- Novel Glue Prevents Complications After Breast Cancer Surgery
- Breakthrough Brain Implant Enables Safer and More Precise Drug Delivery
- Bioadhesive Sponge Stops Uncontrolled Internal Bleeding During Surgery
- Revolutionary Nano Bone Material to Accelerate Surgery and Healing
- Superior Orthopedic Implants Combat Infections and Quicken Healing After Surgery
- Laser-Based Technique Eliminates Pancreatic Tumors While Protecting Healthy Tissue
- Surgical Treatment of Severe Carotid Artery Stenosis Benefits Blood-Brain Barrier
- Revolutionary Reusable Duodenoscope Introduces 68-Minute Sterilization
- World's First Transcatheter Smart Implant Monitors and Treats Congestion in Heart Failure
- Hybrid Endoscope Marks Breakthrough in Surgical Visualization
- Robot-Assisted Bronchoscope Diagnoses Tiniest and Hardest to Reach Lung Tumors
- Diamond-Titanium Device Paves Way for Smart Implants that Warn of Disease Progression
- 3D Printable Bio-Active Glass Could Serve as Bone Replacement Material
- Spider-Inspired Magnetic Soft Robots to Perform Minimally Invasive GI Tract Procedures
- Micro Imaging Device Paired with Endoscope Spots Cancers at Earlier Stage
Channels
Critical Care
view channel
Light-Based Technology to Measure Brain Blood Flow Could Diagnose Stroke and TBI
Monitoring blood flow in the brain is crucial for diagnosing and treating neurological conditions such as stroke, traumatic brain injury (TBI), and vascular dementia. However, current imaging methods like... Read more
AI Heart Attack Risk Assessment Tool Outperforms Existing Methods
For decades, doctors have relied on standardized scoring systems to assess patients with the most common type of heart attack—non-ST-elevation acute coronary syndrome (NSTE-ACS). The GRACE score, used... Read more
Patient Care
view channel
Revolutionary Automatic IV-Line Flushing Device to Enhance Infusion Care
More than 80% of in-hospital patients receive intravenous (IV) therapy. Every dose of IV medicine delivered in a small volume (<250 mL) infusion bag should be followed by subsequent flushing to ensure... Read more
VR Training Tool Combats Contamination of Portable Medical Equipment
Healthcare-associated infections (HAIs) impact one in every 31 patients, cause nearly 100,000 deaths each year, and cost USD 28.4 billion in direct medical expenses. Notably, up to 75% of these infections... Read more
Portable Biosensor Platform to Reduce Hospital-Acquired Infections
Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more
First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds
Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read moreHealth IT
view channel
Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors
The future of medicine is likely to focus on the personalization of healthcare—understanding exactly what an individual requires and delivering the appropriate combination of nutrients, metabolites, and... Read more
Business
view channel
Philips and Masimo Partner to Advance Patient Monitoring Measurement Technologies
Royal Philips (Amsterdam, Netherlands) and Masimo (Irvine, California, USA) have renewed their multi-year strategic collaboration, combining Philips’ expertise in patient monitoring with Masimo’s noninvasive... Read more
B. Braun Acquires Digital Microsurgery Company True Digital Surgery
The high-end microsurgery market in neurosurgery, spine, and ENT is undergoing a significant transformation. Traditional analog microscopes are giving way to digital exoscopes, which provide improved visualization,... Read more
CMEF 2025 to Promote Holistic and High-Quality Development of Medical and Health Industry
The 92nd China International Medical Equipment Fair (CMEF 2025) Autumn Exhibition is scheduled to be held from September 26 to 29 at the China Import and Export Fair Complex (Canton Fair Complex) in Guangzhou.... Read more