Critical Care System Helps Monitor Urine Flow

A novel diagnostics system provides real-time monitoring of urine flow in critical care and peri-operative settings.

The RenalSense (Jerusalem, Israel) Clarity RMS system is an innovative system designed to continuously monitor urine flow. The system uses sophisticated sensor technology and proprietary algorithms in order to measure non-homogeneous, time-varying liquids, even in unstable, uncontrolled environments, automatically transmitting real-time data to medical staff on a 24/7 basis. The approach, which involves complex numeric techniques, is based on an in-depth understanding of fluid dynamics, thermodynamics, human physiology, and target environment properties.

The patented sensor measures, analyzes, and interprets the continuously changing composition and flow volume of urine, generating a unique set of electronic signals that represent ongoing changes in renal function. Proprietary algorithms separate the “noise” from these signals with high sensitivity and stability, achieving clear recognition and correct interpretation of different processes in the extremely dynamic environment. Timely alerts of fluctuations provide an early warning sign of acute kidney injury (AKI) risk, facilitating rapid intervention.

“We've known for years that urine output information is essential for management of critical care patients. The time has come for urine output to be monitored electronically in real-time, as is the standard practice for other vital signs in the ICU,” said Professor John Kellum, MD, of the University of Pittsburgh Medical Center (UPMC, PA, USA).

AKI is common among intensive care unit (ICU) patients, with a broad spectrum of clinical presentations ranging from mild to severe injury that may result in permanent and complete loss of renal function and high mortality. The underlying mechanisms of AKI include a decrease in the kidney's ability to excrete nitrogenous waste, manage electrolytes, regulate intravascular volume, and assist with maintenance of the acid-base status via urine excretion.

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RenalSense
University of Pittsburgh Medical Center