Next Gen Digital Diagnostic Platform to Detect Multiple Pathogens within 5 Minutes at Gene Level
|
By HospiMedica International staff writers Posted on 30 Jun 2023 |
|
An advanced digital diagnostic platform with the capability to detect multiple pathogens in five minutes at the molecular gene level and priced significantly lower than current molecular tests is all set to disrupt the PCR market.
Check4 by IdentifySensors Biologics (Cleveland, OH, USA) is a next-generation digital diagnostic platform that has been developed to detect the genetic material of a wide range of pathogens for over-the-counter and point-of-care use. The Check4 testing platform comprises two components: a reusable Bluetooth reader roughly the size of a mobile phone, and disposable test cartridges that connect to the reader. Each test sample can simultaneously detect up to three different pathogens. Digital graphene sensors within the cartridges target conserved regions of the genome, thereby ensuring high sensitivity and specificity without the need for enzymatic amplification or reagents.
The sensors in the disposable cartridges can be customized to identify a broad range of pathogens that display similar symptoms. Multiplex tests are in development for respiratory pathogens (COVID, RSV, and influenza), gastrointestinal pathogens (Norovirus, Rotavirus, and Adenovirus), and sexually transmitted pathogens (HIV, Hepatitis, Chlamydia, Gonorrhea, and Herpes). Other tests under development include those for SEPSIS, MRSA, Lyme disease, and tropical pathogens such as Zika, Dengue, Yellow Fever, and West Nile virus. Previous research indicates that Check4 can potentially diagnose infections like COVID, RSV, and influenza even before patients exhibit symptoms. IdentifySensors has commenced testing this novel diagnostic device in anticipation of FDA submissions. Clinical studies for the Check4 diagnostic device are slated for this year as part of an extensive testing platform designed to be adapted for detecting a broad range of additional pathogens in the coming years.
"In preliminary studies we have seen encouraging results of this new technology," said Greg Hummer M.D., IdentifySensors co-founder and CEO. "We are excited to test these devices and move forward with additional targets that detect a wide range of infections."
Related Links:
IdentifySensors Biologics
Latest Point of Care News
- Continuous Glucose Monitoring Identifies Cardiometabolic Risk in Adults Without Diabetes
- Microneedle Patch Enables At-Home Monitoring of Acute Kidney Injury
- Ultrathin Metasurface Could Bring Quantitative Phase Imaging to Portable Devices
- Rapid Onsite Testing Reduces Emergency Department Transfers in Long-Term Care
- New Brain Ultrasound Platform Enables Bedside Postoperative Imaging
- Handheld Ultrasound Expands Point-of-Care Imaging Access in Brazil
- AI Dermatology Platform Targets Early Detection of Non-Melanoma Skin Cancer
- Handheld AI Device for Point-of-Care Skin Lesion Assessment Receives CE Mark
- Portable Immunoassay System Advances Toward Point-of-Care Biomarker Testing
- Portable MRI System Accelerates Emergency Brain Imaging and Triage
- Point-of-Care Viscoelastic Testing System Supports Obstetric Bleeding Management
- Portable MRI System Gains CE Mark for Point-of-Care Brain Imaging
Channels
Artificial Intelligence
view channel
AI Tool Improves Hospital Discharge Summaries to Support Follow-Up Care
Discharge summaries guide care after hospitalization but can be difficult to prepare after long or complex stays. Clinicians must condense treatment, medications, follow-up, and unresolved issues into... Read more
AI Tool Predicts Hypertensive Crisis Up to 72 Hours Ahead
A hypertensive crisis is a rapid and severe rise in blood pressure above 180/120 mm Hg accompanied by acute end-organ damage. It can lead to stroke, heart attack, kidney injury, aortic dissection, or pulmonary... Read more
Critical Care
view channel
Circuit-Free Smart Patch Uses Smartphone Camera to Monitor Pulse and Vessel Stiffness
Routine cardiovascular monitoring often relies on electronic sensors, cables, or specialized equipment, which can limit its use beyond hospitals, ambulances, general practice clinics, and emergency rooms.... Read more
Chest Digital Twin Guides Light Therapy Dosing for Pneumonia
Pneumonia is a lung infection that can impair gas exchange and progress to severe respiratory compromise. Light-based therapies may help treat infection or inflammation, but externally applied light must... Read more
Surgical Techniques
view channel
Dual-Technique Approach Improves Stent Expansion in Calcified Coronary Lesions
Calcified coronary nodules are hard, irregular calcium deposits that protrude into coronary arteries and can complicate percutaneous coronary intervention by preventing full stent expansion.... Read more
FDA Approves First Transcatheter Device for Paravalvular Leak Closure
Paravalvular leak is a backflow of blood around a surgical heart valve that can follow valve replacement, causing heart failure symptoms or hemolysis. These leaks occur in 7%–17% of mitral valve replacements... Read more
Patient Care
view channel
Video-Based Support Helps Older Adults Clarify Kidney Disease Treatment Preferences
Advanced chronic kidney disease (CKD) involves progressive loss of kidney function that can lead to kidney failure and difficult treatment decisions. For older adults, these decisions may include choosing... Read more
Expert Review Outlines Diagnosis and Treatment of Recurrent Catheter Infections
Patients who rely on long-term intravenous catheters for chemotherapy, hemodialysis, intravenous nutrition, and other essential therapies remain at risk of catheter-related bloodstream infections.... Read more
Medical Imaging
view channel
Imaging Biomarker Links Breast Tumor Heterogeneity to Targeted Therapy Response
Breast cancer patients can respond differently to targeted therapy, even when their tumors appear similar on conventional imaging. This variability can expose some patients to treatments that provide limited... Read more
AI-Guided Echocardiography Enables Mobile Cardiac Imaging in Rural Communities
Echocardiography uses ultrasound to provide real-time images of cardiac structure and function, but access can be limited in rural communities where testing often depends on expert sonographers, imaging... Read more
Privacy-Preserving AI Tool Synthesizes CT for Radiation Therapy Planning
Radiation therapy planning depends on accurate medical imaging to calculate dose, visualize organs, and position patients during treatment. Hospitals need large imaging datasets to train robust artificial... Read more
Tissue Around Breast Microcalcifications Emerges as a Key Source of Diagnostic Information
Breast microcalcifications are small calcium deposits that are often detected on mammography and digital breast tomosynthesis. Clinicians use their morphology and distribution to assess suspicious breast... Read moreHealth IT
view channel
Clinical Decision Support Tool Automates CKD Risk Assessment in Primary Care
Chronic kidney disease (CKD) requires timely diagnosis, risk assessment, and coordinated treatment in primary care. Delayed recognition can affect decisions about testing, blood pressure control, cardiovascular... Read more
EHR Alerts Support Dosing, Sedation, and Shock Recognition in Cardiac Care
Electronic health record alerts can add to clinician workload when they are poorly targeted. In critical cardiac care, however, delayed decisions can affect treatment timing, sedation exposure, and escalation... Read more
Business
view channel
Steris to Expand Surgical Safety Portfolio With $2.1 Billion Xodus Medical Deal
Steris has signed a definitive agreement to acquire Xodus Medical, a specialty surgical products business based in Pennsylvania, for $2.1 billion at closing. The acquisition will expand Steris’s healthcare... Read more
Stryker Enters Soft-Tissue Robotics Through Strategic Alliance With CMR Surgical
Stryker (Portage, MI, USA) and CMR Surgical (Cambridge, UK) have announced a strategic alliance centered on the Versius Surgical Robotic portfolio. The agreement includes an approximately USD 400 million... Read more
Terumo Neuro Acquisition Advances Liquid Embolic Technology for Chronic Subdural Hematoma
Terumo Neuro (Aliso Viejo, CA, USA) signed an agreement to acquire Arsenal Medical Inc. (Waltham, MA, USA), a privately held, clinical-stage biomaterials company. The proposed acquisition would add NeoCast,... Read more