Next Gen Digital Diagnostic Platform to Detect Multiple Pathogens within 5 Minutes at Gene Level

By HospiMedica International staff writers
Posted on 30 Jun 2023

Image: The Check4 digital diagnostic platform aims to disrupt the PCR market for many infections (Photo courtesy of IdentifySensors)

An advanced digital diagnostic platform with the capability to detect multiple pathogens in five minutes at the molecular gene level and priced significantly lower than current molecular tests is all set to disrupt the PCR market.

Check4 by IdentifySensors Biologics (Cleveland, OH, USA) is a next-generation digital diagnostic platform that has been developed to detect the genetic material of a wide range of pathogens for over-the-counter and point-of-care use. The Check4 testing platform comprises two components: a reusable Bluetooth reader roughly the size of a mobile phone, and disposable test cartridges that connect to the reader. Each test sample can simultaneously detect up to three different pathogens. Digital graphene sensors within the cartridges target conserved regions of the genome, thereby ensuring high sensitivity and specificity without the need for enzymatic amplification or reagents.

The sensors in the disposable cartridges can be customized to identify a broad range of pathogens that display similar symptoms. Multiplex tests are in development for respiratory pathogens (COVID, RSV, and influenza), gastrointestinal pathogens (Norovirus, Rotavirus, and Adenovirus), and sexually transmitted pathogens (HIV, Hepatitis, Chlamydia, Gonorrhea, and Herpes). Other tests under development include those for SEPSIS, MRSA, Lyme disease, and tropical pathogens such as Zika, Dengue, Yellow Fever, and West Nile virus. Previous research indicates that Check4 can potentially diagnose infections like COVID, RSV, and influenza even before patients exhibit symptoms. IdentifySensors has commenced testing this novel diagnostic device in anticipation of FDA submissions. Clinical studies for the Check4 diagnostic device are slated for this year as part of an extensive testing platform designed to be adapted for detecting a broad range of additional pathogens in the coming years.

"In preliminary studies we have seen encouraging results of this new technology," said Greg Hummer M.D., IdentifySensors co-founder and CEO. "We are excited to test these devices and move forward with additional targets that detect a wide range of infections."

Related Links:
IdentifySensors Biologics

Visit expo >

Gold Member

STI Test

Vivalytic Sexually Transmitted Infection (STI) Array

Hand-held Hemoglobin Analyzer
DiaSpect Tm

Pediatric Mask

Respire SOFT

Patient Monitoring System

AlarmSense

Latest Point of Care News

Channels

Artificial Intelligence

view channel

$Image: Mass General Brigham researchers developed two AI tools from one foundation model (called FAHR-Face) that can estimate biological age and predict cancer survival outcomes from a single face photo. The image on the left depicts the features most important to FAHR-FaceSurvival\'s predictions of cancer survival outcomes, while the image on the right shows the features most important to FAHR-FaceAge\'s estimates of biological age. Areas shown in yellow had the greatest influence on each model\'s predictions. (Photo courtesy of Mass General Brigham/Lancet Digital Health)$

$Image: Purdue University physicist David Nolte is developing a biodynamic imaging system that could improve the care of cancer patients undergoing chemotherapy. Nolte\'s system can rapidly evaluate the outcome of different chemotherapy drugs on patient biopsies (obtained during diagnosis), which could ensure patients get the chemotherapy treatment that would be most effective on their specific tumor. Right now, the system is being used at the Indiana University School of Medicine to evaluate the impact of experimental chemotherapy drugs on tumor cells derived from more than 30 osteosarcoma patients. It has also been used in clinical and preclinical trials. (IMage Credit: Purdue University/Kelsey Lefever)$

Optical Imaging System Helps Predict Chemotherapy Response in Cancer

Selecting chemotherapy can be difficult because tumors from different patients may respond differently to the same drug. Testing treatment effects directly on living tumor tissue could help clinicians... Read more

Critical Care

view channel

Smart Medical Adhesive Patch Uses Heat to Enable Gentle Removal

Medical adhesive-related skin injury (MARSI) is a persistent concern for neonates, older adults, critically ill patients, and others requiring repeated monitoring. Strong adhesives keep sensors securely... Read more

Smart Pulse Oximetry Supports Earlier Recognition of Arrhythmias and Respiratory Risk

On general care floors, respiratory compromise and arrhythmias can develop between routine checks. Atrial fibrillation often goes undiagnosed in older adults, while opioid-induced respiratory depression... Read more

Proposed Risk Score Prioritizes Sickest Patients for Heart Transplant

Donor hearts remain extremely scarce in the U.S. transplant system, with one in five candidates dying or being removed from the waiting list before receiving an organ. Current allocation rules may also... Read more

Wearable Robotic Gait Training Linked to Improved Walking Distance in ALS

Amyotrophic lateral sclerosis (ALS) is a progressive neuromuscular disease that damages nerve cells controlling voluntary muscles. As the disease advances, patients can lose the ability to walk, speak,... Read more

Surgical Techniques

view channel

Combined Wound Healing Approach Pairs Synthetic Scaffold With Negative Pressure Therapy

Managing complex wounds requires both structural support for tissue repair and a controlled environment that protects the healing process. Frequent dressing changes can disrupt the wound bed and add complexity... Read more

Shape-Changing Hydrogels Show Promise for Tissue Engineering and Wound Healing

Human tissues often have complex three-dimensional shapes that are closely tied to their function, but recreating these curvatures remains challenging in tissue engineering and wound repair.... Read more

$Image: The new technology uses augmented reality to overlay a 3D visualization of the tumor and other anatomical structures on the surgeon\'s camera view. Here, Niclas Kvarnström, transplant surgeon and head of the Transplant Centre, and Fatuma Shieriye, specialist physician, perform the first operation using the new technology. (Image Credit: Jenny Cedås)$