Organic Compound Stimulates Skin Regeneration in Burns

A novel polymer derived from gallic acid could help promotes skin regeneration in third-degree burn patients, according to a new study.

Developed by researchers at the National University of Mexico (UNAM; Mexico City), the new, water-soluble polymer, named gallic polyacid, has antimicrobial and antioxidant capacities that could be implemented in a range of applications, including wound management for diabetics, medical patches for skin regeneration, and as a semiconductor component of electrochromic cells, such as those used in smart polychromic windows. Other possible applications include use as an additive for free endocrine disruption, and in biodegradable food packaging.

The researchers are currently performing laboratory test in collaboration with the National Institute for Rehabilitation (INR; Mexico City, Mexico) in the creation of cellulose films loaded with gallic polyacid that could stimulate regeneration of the skin in patients with third-degree burns, where the polymer can act as an agent against bacteria populating ulcerating wounds. According to the researchers, this is made possible by anchoring the gallic polyacid molecule to other biopolymers with film-forming ability.

“We succeeded via a defined molecular structure to achieve improved biological availability. It has antioxidant and antimicrobial and qualities, which are useful in biomedicine and food,” said Miquel Gimeno Seco, PhD, head of research at the UNAM school of chemistry. “Being soluble, the molecule could be incorporated into the affected area, acting against resistant bacteria. One of the challenges [facing us] is to ensure that natural materials are efficient and cheap as inorganic catalysts.”

Gallic acid is a colorless crystalline organic powder that occurs as a free molecule or as part of a tannin molecule. It is found in almost all plants, with especially high content in gallnuts, grapes, tea, hops, blueberries, and oak bark. Gallic acid seems to have antifungal, antiviral, and antibacterial properties, and has been found to show cytotoxicity against cancer cells, without harming healthy cells. Other uses include serving as an astringent in internal hemorrhage ad in ointments to treat psoriasis and external hemorrhoids.

Related Links:
National University of Mexico
National Institute for Rehabilitation