We use cookies to understand how you use our site and to improve your experience. This includes personalizing content and advertising. To learn more, click here. By continuing to use our site, you accept our use of cookies. Cookie Policy.

Aalto Bio Launches New Recombinant Eukaryotic SARS-CoV-2, S1-S2 Spike Proteins for COVID-19 Testing

By HospiMedica International staff writers
Posted on 26 May 2020

Illustration

Aalto Bio Reagents Ltd. (Dublin, Ireland) has launched its new range of recombinant SARS-CoV-2 spike (S) proteins for diagnostic test manufacturers, vaccine developers and researchers globally.

Among all structural proteins of SARS-CoV-2, the S protein is the main antigenic component that is responsible for inducing host immune responses and neutralizing antibodies. This makes it the principal focus of therapeutic and vaccine design for COVID-19. The S protein of SARS-CoV-2 is located on the surface of the viral particles and is comprised of two functional units, S1 and S2. The N-terminal S1 subunit is responsible for virus-receptor binding and the C-terminal S2 subunit mediates virus-cell membrane fusion. When used solely or in combination with our new insect-derived Nucleocapsid protein (N) (code BM 6424), our S1-S2 chimeric glycoprotein (code BM 6422) has demonstrated excellent reactivity in ELISA for detection of IgA, IgG and IgM antibodies against SARS-CoV-2.

"Patients continue to be screened for the virus by PCR on the front line," said Philip Noone, CEO of Aalto Bio Reagents, "however there is an important need for serological tests as well to detect all those mild or even asymptomatic cases that may otherwise be missed. Having diagnostic tests that can work in different healthcare settings will be the critical next step in battling this virus and crucial to their development is the selection of high-quality, raw materials used to design them. Our new S1, S2 glycoproteins and S1-S2 Chimeric proteins, in addition to our E. coli-derived N protein launched in February, have been rapidly developed to meet this urgent need."

Related Links:
Aalto Bio Reagents Ltd.

Visit expo >

Gold Member

12-Channel ECG

CM1200B

Antipsychotic TDM Assays
Saladax Antipsychotic Assays

New

Medical-Grade Display

HL2316SHTB

New

Monitor/Defibrillator

Zenix

Latest COVID-19 News

Channels

Artificial Intelligence

view channel

AI Analysis of Pericardial Fat Refines Long-Term Heart Disease Risk

Accurately identifying long-term cardiovascular disease risk in asymptomatic adults remains challenging for clinicians. Missed or underestimated risk delays preventive therapy and increases the chance... Read more

Machine Learning Approach Enhances Liver Cancer Risk Stratification

Hepatocellular carcinoma, the most common form of primary liver cancer, is often detected late despite targeted surveillance programs. Current screening guidelines emphasize patients with known cirrhosis,... Read more

Image: connected devices offer new possibilities in the early detection of abnormalities or changes in brain health (Photo courtesy of 123RF)

New AI Approach Monitors Brain Health Using Passive Wearable Data

Brain health spans cognitive and emotional functions and can fluctuate even in adults without diagnosed disease. Detecting early changes remains difficult in routine care and burdens specialty services... Read more

$Image: Study procedure flow chart. After patients with BSI were identified from microbiology databases, 27 patients\' characteristics were extracted from electronic health records. After the dimension of those variables was reduced with Uniform Manifold Approximation and Projection (UMAP), k-means++ was used to identify clusters. Three clinically distinct clusters were identified. Among those clusters, patients were divided into solid organ transplant (SOT) and non-SOT groups. Clinical characteristics and outcomes were evaluated (Masayuki Nigo et al., American Journal of Transplantation (2026). DOI: 10.1016/j.ajt.2025.10.019)$

AI Tool Maps Early Risk Patterns in Bloodstream Infections

Bloodstream infections can deteriorate rapidly and carry high mortality, especially in immunocompromised patients. Clinicians need reliable early risk stratification to prioritize monitoring and organ support.... Read more

Critical Care

view channel

Image: FFRangio combines AI and software to generate 3D coronary models and quantify blood flow restriction in narrowed arteries (photo courtesy of CathWorks)

Angiography-Based FFR Approach Matches Gold Standard Results Without Wires

Accurately determining whether a coronary stenosis limits blood flow is essential to guide percutaneous coronary intervention, yet wire-based physiologic testing remains underused due to added procedural... Read more

Image: The algorithm was trained to recognize patterns in retinal vasculature that are associated with the development of heart disease (photo courtesy of 123RF)

Eye Imaging AI Identifies Elevated Cardiovascular Risk

Many adults at risk for atherosclerotic cardiovascular disease are not identified until they undergo formal primary care assessment. Delayed risk recognition can postpone initiation of statins and lifestyle... Read more

Noninvasive Monitoring Device Enables Earlier Intervention in Heart Failure

Hospitalizations for heart failure with preserved ejection fraction (HFpEF) remain common because lung congestion often worsens before symptoms prompt treatment changes. Missed early decompensation... Read more

Automated IV Labeling Solution Improves Infusion Safety and Efficiency

Medication administration in high-acuity settings is often complicated by multiple concurrent infusions, making accurate line identification essential. In a 10-hospital intensive care unit study, 60% of... Read more

Surgical Techniques

view channel

Fiber-Form Bone Graft Expands Intraoperative Options for Spinal Fusion

Spinal and orthopedic fusion procedures often require bone graft materials that handle predictably and support bone formation. Surgeons face added complexity in difficult anatomy and challenging fusion environments.... Read more

Ultrasound‑Aided Catheter Treatment Cuts Early Collapse in Pulmonary Embolism

Acute pulmonary embolism can cause rapid hemodynamic deterioration and early death in hospitalized and emergency patients. Systemic thrombolysis can dissolve clots but is limited by a high risk of major... Read more

Ultrasound Technology Aims to Replace Invasive BPH Procedures

Benign prostatic hyperplasia (BPH) is a frequent cause of lower urinary tract symptoms in aging men and often requires invasive procedures or prolonged recovery. With prevalence expected to rise as populations... Read more

Continuous Monitoring with Wearables Enhances Postoperative Patient Safety

Postoperative hypoxemia on general surgical wards is common and often missed by intermittent vital sign checks. Undetected low oxygen levels can delay recovery and raise the risk of complications that... Read more

Patient Care

view channel

Wearable Sleep Data Predict Adherence to Pulmonary Rehabilitation

Chronic obstructive pulmonary disease (COPD) is a long-term lung disorder that makes breathing difficult and often disturbs sleep, reducing energy for daily activities. Limited engagement in pulmonary... Read more

Image: The revolutionary automatic IV-Line flushing device set for launch in the EU and US in 2026 (Photo courtesy of Droplet IV)

Revolutionary Automatic IV-Line Flushing Device to Enhance Infusion Care

More than 80% of in-hospital patients receive intravenous (IV) therapy. Every dose of IV medicine delivered in a small volume (<250 mL) infusion bag should be followed by subsequent flushing to ensure... Read more

Image: A screengrab from the VR training module that shows invisible contamination on portable medical equipment (Photo courtesy of Mass General Brigham)

VR Training Tool Combats Contamination of Portable Medical Equipment

Healthcare-associated infections (HAIs) impact one in every 31 patients, cause nearly 100,000 deaths each year, and cost USD 28.4 billion in direct medical expenses. Notably, up to 75% of these infections... Read more

Image: The portable biosensor platform uses printed electrochemical sensors for the rapid, selective detection of Staphylococcus aureus (Photo courtesy of AIMPLAS)

Portable Biosensor Platform to Reduce Hospital-Acquired Infections

Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more

Health IT

view channel

Voice-Driven AI System Enables Structured GI Procedure Documentation

Documentation during gastrointestinal (GI) procedures often competes with real-time clinical decision-making and imposes a significant cognitive burden on physicians. Manual data entry and post-procedure... Read more

mage: The EHR–driven tool could help doctors intervene earlier to protect transplanted kidneys (Photo courtesy of 123RF)

EMR-Based Tool Predicts Graft Failure After Kidney Transplant

Kidney transplantation offers patients with end-stage kidney disease longer survival and better quality of life than dialysis, yet graft failure remains a major challenge. Although a successful transplant... Read more

Image: A wearable sweat sensor based on the core–shell nanoparticle technology (Photo courtesy of Caltech)

Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors

The future of medicine is likely to focus on the personalization of healthcare—understanding exactly what an individual requires and delivering the appropriate combination of nutrients, metabolites, and... Read more

Image: Smartwatches could provide more affordable and accessible cardiac monitoring (Photo courtesy of 123RF)

Smartwatches Could Detect Congestive Heart Failure

Diagnosing congestive heart failure (CHF) typically requires expensive and time-consuming imaging techniques like echocardiography, also known as cardiac ultrasound. Previously, detecting CHF by analyzing... Read more

Point of Care

view channel

Image: The Nevisense uses a non-invasive procedure that combines EIS technology with AI to provide in-depth skin analysis (photo courtesy of SciBase)

AI-Enabled Platform Supports Clinical Decision-Making in Melanoma Detection

Visual examination remains the foundation of dermatologic assessment for suspicious skin lesions, and many dermatologists are confident using clinical and dermoscopic techniques. However, studies show... Read more

Business

view channel

GE HealthCare Leads Major European Initiative to Advance Cardio-Oncology Care

Cardiovascular complications are increasingly recognized among people undergoing or recovering from cancer treatment, driven by pre‑existing disease and the cardiotoxic effects of chemotherapy, radiotherapy,... Read more

Medtronic and GE HealthCare Broaden Alliance Across Monitoring and Care Solutions

Medtronic announced a multiyear renewal and significant expansion of its global strategic alliance with GE HealthCare across Patient Care Solutions. Building on more than three decades of collaboration,... Read more

Image: NeuWave’s microwave ablation system is used in percutaneous tumor ablation procedures (photo courtesy of NeuWave Medical)

Quantum Surgical Acquires NeuWave from Johnson & Johnson

Quantum Surgical announced that it has acquired NeuWave Medical from Johnson & Johnson. NeuWave’s microwave ablation system is used in percutaneous tumor ablation procedures, and the acquisition supports... Read more

Image: Medtronic’s intent to acquire CathWorks follows a 2022 strategic partnership with a co-promotion agreement for the FFRangio System (Photo courtesy of CathWorks)

Medtronic to Acquire Coronary Artery Medtech Company CathWorks

Medtronic plc (Galway, Ireland) has announced that it will exercise its option to acquire CathWorks (Kfar Saba, Israel), a privately held medical device company, which aims to transform how coronary artery... Read more