New Antibiotic Kills Pathogens Without Detectable Resistance
By HospiMedica International staff writers Posted on 20 Jan 2015 |
Image: The iChip being removed from soil (Photo courtesy of Northeastern University).
The first new antibiotic to be discovered in nearly 30 years could revolutionize the fight against the growing antibiotic resistance, claims a new study.
Researchers at the University of Bonn (Germany), Northeastern University (Boston, MA, USA), and other institutions have discovered a new antibiotic, which they named teixobactin, which inhibits cell wall synthesis by binding to lipid II, and is different in its action than other glycopeptide drugs, such as vancomycin or dalbavancin. Teixobactin was highly effective against common Gram positive bacteria, such as Clostridium difficile, Mycobacterium tuberculosis, and Staphylococcus aureus, but was ineffective against Gram negative pathogens.
The discovery was made possible using a new technique called the iChip, which is made of a lattice of wells holding individual bacteria within agar. Once loaded with bacteria, the iChip is covered with a permeable membrane and replaced into the original soil. Using the technique, the researchers were able to screen 10,000 previously unculturable bacteria, discovered a new bacteria, Eleftheria terrae, and 25 new compounds, among them teixobactin, the most promising one to date.
In mouse studies, teixobactin showed 100% efficacy against methicillin-resistant Staphylococcus aureus (MRSA) sepsis in thigh infection, and was very active against S. pneumoniae in lungs. No toxicity and no hemolytic activity were seen against the mammal cells tested, and the drug did not bind DNA, leading the researchers to be optimistic about its overall toxicity. The first clinical trials on humans could begin in two years and, if successful, the drug could be in widespread use in 10 years. The study describing teixobactin and the iChip was published on January 7, 2015, in Nature.
“Bacteria develop resistance by mutations in their proteins. The targets of teixobactin are not proteins, they are polymer precursors of cell wall building blocks so there is really nothing to mutate,” said senior author, Prof. Kim Lewis, PhD, director of the antimicrobial discovery center at Northeastern University. “Apart from the immediate implementation, there is also, I think, a paradigm shift in our minds, because we have been operating on the basis that resistance development is inevitable and that we have to focus on introducing drugs faster than resistance.”
The “golden age” of antibiotic discovery was achieved by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s, since 99% of microbes will not grow in laboratory conditions. The advent of the iChip could aid growing the microbes in the soil, and then isolating their antibiotic chemical compounds.
Related Links:
University of Bonn
Northeastern University
Researchers at the University of Bonn (Germany), Northeastern University (Boston, MA, USA), and other institutions have discovered a new antibiotic, which they named teixobactin, which inhibits cell wall synthesis by binding to lipid II, and is different in its action than other glycopeptide drugs, such as vancomycin or dalbavancin. Teixobactin was highly effective against common Gram positive bacteria, such as Clostridium difficile, Mycobacterium tuberculosis, and Staphylococcus aureus, but was ineffective against Gram negative pathogens.
The discovery was made possible using a new technique called the iChip, which is made of a lattice of wells holding individual bacteria within agar. Once loaded with bacteria, the iChip is covered with a permeable membrane and replaced into the original soil. Using the technique, the researchers were able to screen 10,000 previously unculturable bacteria, discovered a new bacteria, Eleftheria terrae, and 25 new compounds, among them teixobactin, the most promising one to date.
In mouse studies, teixobactin showed 100% efficacy against methicillin-resistant Staphylococcus aureus (MRSA) sepsis in thigh infection, and was very active against S. pneumoniae in lungs. No toxicity and no hemolytic activity were seen against the mammal cells tested, and the drug did not bind DNA, leading the researchers to be optimistic about its overall toxicity. The first clinical trials on humans could begin in two years and, if successful, the drug could be in widespread use in 10 years. The study describing teixobactin and the iChip was published on January 7, 2015, in Nature.
“Bacteria develop resistance by mutations in their proteins. The targets of teixobactin are not proteins, they are polymer precursors of cell wall building blocks so there is really nothing to mutate,” said senior author, Prof. Kim Lewis, PhD, director of the antimicrobial discovery center at Northeastern University. “Apart from the immediate implementation, there is also, I think, a paradigm shift in our minds, because we have been operating on the basis that resistance development is inevitable and that we have to focus on introducing drugs faster than resistance.”
The “golden age” of antibiotic discovery was achieved by screening soil microorganisms, but this limited resource of cultivable bacteria was overmined by the 1960s, since 99% of microbes will not grow in laboratory conditions. The advent of the iChip could aid growing the microbes in the soil, and then isolating their antibiotic chemical compounds.
Related Links:
University of Bonn
Northeastern University
Latest Critical Care News
- Powerful AI Risk Assessment Tool Predicts Outcomes in Heart Failure Patients
- Peptide-Based Hydrogels Repair Damaged Organs and Tissues On-The-Spot
- One-Hour Endoscopic Procedure Could Eliminate Need for Insulin for Type 2 Diabetes
- AI Can Prioritize Emergecny Department Patients Requiring Urgent Treatment
- AI to Improve Diagnosis of Atrial Fibrillation
- Stretchable Microneedles to Help In Accurate Tracking of Abnormalities and Identifying Rapid Treatment
- Machine Learning Tool Identifies Rare, Undiagnosed Immune Disorders from Patient EHRs
- On-Skin Wearable Bioelectronic Device Paves Way for Intelligent Implants
- First-Of-Its-Kind Dissolvable Stent to Improve Outcomes for Patients with Severe PAD
- AI Brain-Age Estimation Technology Uses EEG Scans to Screen for Degenerative Diseases
- Wheeze-Counting Wearable Device Monitors Patient's Breathing In Real Time
- Wearable Multiplex Biosensors Could Revolutionize COPD Management
- New Low-Energy Defibrillation Method Controls Cardiac Arrhythmias
- New Machine Learning Models Help Predict Heart Disease Risk in Women
- Deep-Learning Model Predicts Arrhythmia 30 Minutes before Onset
- Breakthrough Technology Combines Detection and Treatment of Nerve-Related Disorders in Single Procedure