Liver Resection Promotes Long-Term Survival
By HospiMedica International staff writers Posted on 09 Mar 2015 |
A new study shows that in situ split (ISS) liver resection can provide long-term survival for patients with advanced liver malignancies.
Researchers at University Hospital Regensburg (Germany) conducted a study that retrospectively analyzed 16 patients who underwent ISS liver resection between 2007 and 2014. The procedure involves a novel method to induce rapid hypertrophy of the contra-lateral liver lobe, and is intended for patients at risk of postoperative liver failure due to an insufficient amount of liver tissue remaining after the resection. Two patients were lost in early postoperative phase (90 days), and one was lost during follow-up.
Of the remaining 13 patients with a follow-up period of more than 3 months, seven suffered from colorectal liver metastases (CRLM), and six from various other liver malignancies (non-CRLM). The ISS procedure resulted in a median increase of 86.3% of the left lateral liver lobe after a median time period of nine days. The median disease-free survival (DFS) time was 14.6 months, and the median overall survival was 41.7 months (reduced to 26.4 months when including 90-days mortality). The three-year survival rate was 64.3% for the CRLM and 50% for the non-CRLM patients. The study was published in the February 2015 issue of Langenbeck's Archives of Surgery.
“We retrospectively analyzed our patients treated with ISS liver resection at the department of surgery of the University of Regensburg, the first center worldwide to perform ISS,” concluded lead author Sven Lang, MD, and colleagues. “ISS liver resection can provide long-term survival of selected patients with advanced liver malignancies that otherwise are not eligible for liver resection due to insufficient liver remnant.”
ISS, also known as associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) combines portal vein ligation and complete parenchymal transaction, splitting the lobe along the right side of the falciform ligament. After a median of nine days, the segments increase by about 75%, allowing for the subsequent hepatectomy.
Related Links:
University Hospital Regensburg
Researchers at University Hospital Regensburg (Germany) conducted a study that retrospectively analyzed 16 patients who underwent ISS liver resection between 2007 and 2014. The procedure involves a novel method to induce rapid hypertrophy of the contra-lateral liver lobe, and is intended for patients at risk of postoperative liver failure due to an insufficient amount of liver tissue remaining after the resection. Two patients were lost in early postoperative phase (90 days), and one was lost during follow-up.
Of the remaining 13 patients with a follow-up period of more than 3 months, seven suffered from colorectal liver metastases (CRLM), and six from various other liver malignancies (non-CRLM). The ISS procedure resulted in a median increase of 86.3% of the left lateral liver lobe after a median time period of nine days. The median disease-free survival (DFS) time was 14.6 months, and the median overall survival was 41.7 months (reduced to 26.4 months when including 90-days mortality). The three-year survival rate was 64.3% for the CRLM and 50% for the non-CRLM patients. The study was published in the February 2015 issue of Langenbeck's Archives of Surgery.
“We retrospectively analyzed our patients treated with ISS liver resection at the department of surgery of the University of Regensburg, the first center worldwide to perform ISS,” concluded lead author Sven Lang, MD, and colleagues. “ISS liver resection can provide long-term survival of selected patients with advanced liver malignancies that otherwise are not eligible for liver resection due to insufficient liver remnant.”
ISS, also known as associated liver partition and portal vein ligation for staged hepatectomy (ALPPS) combines portal vein ligation and complete parenchymal transaction, splitting the lobe along the right side of the falciform ligament. After a median of nine days, the segments increase by about 75%, allowing for the subsequent hepatectomy.
Related Links:
University Hospital Regensburg
Latest Surgical Techniques News
- Miniaturized Implantable Multi-Sensors Device to Monitor Vessels Health
- Tiny Robots Made Out Of Carbon Could Conduct Colonoscopy, Pelvic Exam or Blood Test
- Miniaturized Ultrasonic Scalpel Enables Faster and Safer Robotic-Assisted Surgery
- AI Assisted Reading Tool for Small Bowel Video Capsule Endoscopy Detects More Lesions
- First-Ever Contact Force Pulsed Field Ablation System to Transform Treatment of Ventricular Arrhythmias
- Caterpillar Robot with Built-In Steering System Crawls Easily Through Loops and Bends
- Tiny Wraparound Electronic Implants to Revolutionize Treatment of Spinal Cord Injuries
- Small, Implantable Cardiac Pump to Help Children Awaiting Heart Transplant
- Gastrointestinal Imaging Capsule a Game-Changer in Esophagus Surveillance and Treatment
- World’s Smallest Laser Probe for Brain Procedures Facilitates Ablation of Full Range of Targets
- Artificial Intelligence Broadens Diagnostic Abilities of Conventional Coronary Angiography
- AI-Powered Surgical Visualization Tool Supports Surgeons' Visual Recognition in Real Time
- Cutting-Edge Robotic Bronchial Endoscopic System Provides Prompt Intervention during Emergencies
- Handheld Device for Fluorescence-Guided Surgery a Game Changer for Removal of High-Grade Glioma Brain Tumors
- Porous Gel Sponge Facilitates Rapid Hemostasis and Wound Healing
- Novel Rigid Endoscope System Enables Deep Tissue Imaging During Surgery