Implant Envelope Forms Vascularized Tissue Pocket

A novel extracellular matrix (ECM) pouch creates a stable environment for cardiac implantable electronic devices (CIEDs).

The CorMatrix CanGaroo ECM envelope is constructed from a multi-laminate sheet of decellularized, lyophilized ECM derived from porcine small intestinal submucosa. The ECM serves as a bioscaffold for vascular ingrowth from adjacent tissues that deliver progenitor cells and nutrients, which then differentiate into tissue-specific cells and structures. The ECM material is then naturally degraded and resorbed, gradually replaced by the patient’s own cells, leaving behind remodeled functional tissue that may ease CIED removal during exchanges or revisions.

The ECM envelope, which is provided in four different sizes, is intended to hold an array of different CIEDs, including pacemakers, cardiac resynchronization therapy (CRT) devices, and implantable cardioverter defibrillators (ICDs). It is positioned after the cardiac surgical procedure has been completed to provide stabilization, support, and reinforcement of the pocket, reducing the risk of device migration and erosion. The CorMatrix CanGaroo ECM Envelope is a product of CorMatrix (Rosewell, GA, USA), and has received the European Community CE mark of approval.

ECM is a collection of extracellular molecules that provides structural and biochemical support to the surrounding cells. It includes the interstitial matrix, composed of polysaccharide gels and fibrous proteins, and the basement membrane, which are sheet-like depositions on which various epithelial cells rest. Each type of connective tissue has a different ECM; collagen fibers and bone mineral comprise the ECM of bone tissue; reticular fibers and ground substance comprise the ECM of loose connective tissue; and blood plasma is the ECM of blood.

Related Links:
CorMatrix