Handheld Fluorescence Imaging Device Aids Wound Management
By HospiMedica International staff writers Posted on 16 Dec 2019 |
Image: The MolecuLight i:X handheld device uses fluorescence imaging to identify bacteria (Photo courtesy of MolecuLight)
A portable fluorescence imaging device enables real time point-of-care (POC) visualization of bacterial presence in wounds, digitally recording images and area measurements.
The MolecuLight (Toronto, Canada) i:X device aids visualization and quantitative tracking of bacterial contamination, wound healing, and connective tissue remodeling of surgical sites and wounds, by the analysis of intrinsic fluorescence signals resulting from illumination with a violet light. The narrow band emitted light causes endogenous fluorophores in the bacteria to fluoresce, without the need of contrast agents. Images can be captured and documented as either stills or videos, including in the surrounding areas where more potentially harmful bacteria may be lurking.
Studies have shown the device can enable real-time POC visualization of discrete focal areas of bacterial colonization in midline abdominal wounds, with a sensitivity of 80% and a specificity of 70%, helping to reduce the likelihood of administering unnecessary antibiotic treatment. Susceptible bacteria include methicillin-resistant Staphylococcus aureus (MRSA); Pseudomonas aeruginosa; Escherichia coli; Coagulase-negative staphylococci; multiple Enterococcus species; multiple Proteus species; Klebsiella pneumonia; Beta-hemolytic streptococci (Group B); and multiple Enterobacter species.
“Identifying wounds with bacterial loads higher than 104 CFU/g at the point-of-care enables the clinician using the MolecuLight i:X to provide more appropriate, targeted treatment,” said Anil Amlani, CEO of MolecuLight. “Our clinical study results demonstrate that the i:X used in combination with clinical signs and symptoms significantly increases the ability of clinicians to identify wounds with the presence of these bacterial loads, when compared with wound assessment based on clinical signs and symptoms alone.”
Low-intensity violet light in the 405 nm range excites tissues and bacteria within and around a wound, causing healthy tissues to fluoresce green, while bacteria fluoresce in either red or cyan. This enables their immediate localization; and while surface bacteria generally appear as a brighter red, subsurface bacteria at the maximal detectable depth of about 1.5 mm appear more blush-colored.
Related Links:
MolecuLight
The MolecuLight (Toronto, Canada) i:X device aids visualization and quantitative tracking of bacterial contamination, wound healing, and connective tissue remodeling of surgical sites and wounds, by the analysis of intrinsic fluorescence signals resulting from illumination with a violet light. The narrow band emitted light causes endogenous fluorophores in the bacteria to fluoresce, without the need of contrast agents. Images can be captured and documented as either stills or videos, including in the surrounding areas where more potentially harmful bacteria may be lurking.
Studies have shown the device can enable real-time POC visualization of discrete focal areas of bacterial colonization in midline abdominal wounds, with a sensitivity of 80% and a specificity of 70%, helping to reduce the likelihood of administering unnecessary antibiotic treatment. Susceptible bacteria include methicillin-resistant Staphylococcus aureus (MRSA); Pseudomonas aeruginosa; Escherichia coli; Coagulase-negative staphylococci; multiple Enterococcus species; multiple Proteus species; Klebsiella pneumonia; Beta-hemolytic streptococci (Group B); and multiple Enterobacter species.
“Identifying wounds with bacterial loads higher than 104 CFU/g at the point-of-care enables the clinician using the MolecuLight i:X to provide more appropriate, targeted treatment,” said Anil Amlani, CEO of MolecuLight. “Our clinical study results demonstrate that the i:X used in combination with clinical signs and symptoms significantly increases the ability of clinicians to identify wounds with the presence of these bacterial loads, when compared with wound assessment based on clinical signs and symptoms alone.”
Low-intensity violet light in the 405 nm range excites tissues and bacteria within and around a wound, causing healthy tissues to fluoresce green, while bacteria fluoresce in either red or cyan. This enables their immediate localization; and while surface bacteria generally appear as a brighter red, subsurface bacteria at the maximal detectable depth of about 1.5 mm appear more blush-colored.
Related Links:
MolecuLight
Latest Critical Care News
- On-Skin Wearable Bioelectronic Device Paves Way for Intelligent Implants
- First-Of-Its-Kind Dissolvable Stent to Improve Outcomes for Patients with Severe PAD
- AI Brain-Age Estimation Technology Uses EEG Scans to Screen for Degenerative Diseases
- Wheeze-Counting Wearable Device Monitors Patient's Breathing In Real Time
- Wearable Multiplex Biosensors Could Revolutionize COPD Management
- New Low-Energy Defibrillation Method Controls Cardiac Arrhythmias
- New Machine Learning Models Help Predict Heart Disease Risk in Women
- Deep-Learning Model Predicts Arrhythmia 30 Minutes before Onset
- Breakthrough Technology Combines Detection and Treatment of Nerve-Related Disorders in Single Procedure
- Plasma Irradiation Promotes Faster Bone Healing
- New Device Treats Acute Kidney Injury from Sepsis
- Study Confirms Safety of DCB-Only Strategy for Treating De Novo Left Main Coronary Artery Disease
- Revascularization Improves Quality of Life for Patients with Chronic Limb Threatening Ischemia
- AI-Driven Prediction Models Accurately Predict Critical Care Patient Deterioration
- Preventive PCI for High-Risk Coronary Plaques Reduces Cardiac Events
- AI Diagnostic Tool Guides Rapid Diagnosis and Prediction of Sepsis