ECG Can Pinpoint Hospitalized COVID-19 Patients at High Risk of Death
By HospiMedica International staff writers Posted on 05 Apr 2022 |

An electrocardiogram (ECG) records electrical activity as it travels through the heart. The information is displayed as a graph which is divided into sections according to the location in the heart. QT interval refers to the electrical signal from the moment the ventricles of the heart contract until they finish relaxing and is measured in milliseconds. Patients with a prolonged QT interval are at increased risk for life-threatening arrhythmias (heart rhythm disorders) and cardiac arrest. Now, a new study that examined the association between QT prolongation and long-term mortality in patients hospitalized with COVID-19 has found that ECG can pinpoint hospitalized COVID-19 patients at high risk of death who might need intensive management. The study, which also evaluated the relationship between prolonged QT interval and myocardial injury, a condition in which cells in the heart die, further revealed that a prolonged QT interval on the ECG was an independent risk factor for both myocardial injury and one-year mortality.
The study by researchers at the Tel Aviv Sourasky Medical Center (Tel Aviv, Israel) involved a total of 335 consecutive patients hospitalized with COVID-19. All the patients had an ECG upon admission. Patients were deemed to have myocardial injury if they showed reduced function on an echocardiogram, which is an ultrasound of the heart, and/or had troponin in the bloodstream. Troponin is a protein found only in heart cells. When the heart is damaged, for example in myocardial injury, troponin is released into the bloodstream. Patients were divided into two groups according to the duration of the QT interval: 109 patients (32.5%) had a prolonged QT interval and 226 patients (67.5%) had a normal QT interval. Compared to those with a normal QT interval, patients with a prolonged QT interval were older (70 years on average versus 63 years), more often had co-existing conditions such as hypertension, diabetes and congestive heart failure and presented more frequently with severe (as opposed to mild) COVID-19.
Some 78 patients (71.6%) with QT prolongation had myocardial injury compared to 110 (48.7%) with a normal QT interval. Prolonged QT was associated with a two-fold increased risk of myocardial injury after adjusting for age, co-existing conditions and severity of COVID-19. At one year, 41% of patients in the prolonged QT interval group had died compared to 17% in the normal QT interval group. QT prolongation was associated with a 1.85-fold increased risk of dying within a year after adjusting for age, co-existing conditions and severity of COVID-19. When patients were divided into four groups according to the presence of myocardial injury (yes/no) and QT prolongation (yes/no), those with both conditions had a 6.6-fold higher likelihood of one-year mortality compared to patients without QT prolongation and no myocardial injury.
“An ECG is an inexpensive, non-invasive, easily attainable and widely available test applied in nearly all hospitalized patients,” said lead author Dr. Ariel Banai of Tel Aviv Sourasky Medical Center. “Our study suggests that a simple ECG tracing performed upon admission may help healthcare professionals to triage patients with COVID-19 and identify those in need of intensive care.”
“Interestingly, among patients with myocardial injury half had no troponin in the blood, suggesting blood tests alone may miss a substantial number of patients with this heart problem,” added Dr. Banai. “In our study, one-third of hospitalized COVID-19 patients had a prolonged QT interval. These patients were generally older and sicker but even after adjusting for these factors, prolonged QT interval was independently associated with worse survival. More studies are needed to confirm our observations, but the results indicate that ECG assessment could play a role in the risk stratification of patients admitted with COVID-19 infection.”
Related Links:
Tel Aviv Sourasky Medical Center
Latest COVID-19 News
- Low-Cost System Detects SARS-CoV-2 Virus in Hospital Air Using High-Tech Bubbles
- World's First Inhalable COVID-19 Vaccine Approved in China
- COVID-19 Vaccine Patch Fights SARS-CoV-2 Variants Better than Needles
- Blood Viscosity Testing Can Predict Risk of Death in Hospitalized COVID-19 Patients
- ‘Covid Computer’ Uses AI to Detect COVID-19 from Chest CT Scans
- MRI Lung-Imaging Technique Shows Cause of Long-COVID Symptoms
- Chest CT Scans of COVID-19 Patients Could Help Distinguish Between SARS-CoV-2 Variants
- Specialized MRI Detects Lung Abnormalities in Non-Hospitalized Long COVID Patients
- AI Algorithm Identifies Hospitalized Patients at Highest Risk of Dying From COVID-19
- Sweat Sensor Detects Key Biomarkers That Provide Early Warning of COVID-19 and Flu
- Study Assesses Impact of COVID-19 on Ventilation/Perfusion Scintigraphy
- CT Imaging Study Finds Vaccination Reduces Risk of COVID-19 Associated Pulmonary Embolism
- Third Day in Hospital a ‘Tipping Point’ in Severity of COVID-19 Pneumonia
- Longer Interval Between COVID-19 Vaccines Generates Up to Nine Times as Many Antibodies
- AI Model for Monitoring COVID-19 Predicts Mortality Within First 30 Days of Admission
- AI Predicts COVID Prognosis at Near-Expert Level Based Off CT Scans
Channels
Artificial Intelligence
view channel
Innovative Risk Score Predicts Heart Attack or Stroke in Kidney Transplant Candidates
Heart researchers have utilized an innovative risk assessment score to accurately predict whether patients being evaluated for kidney transplants are at risk for future major cardiac events, such as a... Read more
AI Algorithm Detects Early-Stage Metabolic-Associated Steatotic Liver Disease Using EHRs
Liver disease, which is treatable when detected early, often goes unnoticed until it reaches advanced stages. Metabolic-associated steatotic liver disease (MASLD), the most prevalent form of liver disease,... Read moreCritical Care
view channel
Novel Coating Significantly Extends Longevity of Implantable Biosensors
Wearable and implantable biosensors capable of accurately detecting biological molecules in a non-invasive or minimally invasive way offer enormous potential for monitoring patients’ health and their responses... Read more
Nanogel-Based Drug Delivery Technology to Improve UTI Treatment
Urinary tract infections (UTIs) are not only widespread and costly but also highly debilitating, significantly impacting the quality of life for those affected. The antibiotics commonly used to treat UTIs... Read more
New IV Pole Improves Safety and Ease of Administering IV Medications at Hospital Bedside
Preventable medication errors affect around 500,000 hospitalized patients in the U.S. every year. A significant portion of these errors occur with intravenous (IV) smart pumps, which require a precise... Read moreSurgical Techniques
view channel
Easy-To-Apply Gel Could Prevent Formation of Post-Surgical Abdominal Adhesions
Surgical adhesions are a frequent and often life-threatening complication following open or laparoscopic abdominal surgery. These adhesions develop in the weeks following surgery as the body heals.... Read more
Groundbreaking Leadless Pacemaker to Prevent Invasive Surgeries for Children
Leadless pacemakers marked a significant advancement in cardiac care, primarily because traditional pacemakers are dependent on leads, which are prone to breakage over time. Currently, two FDA-approved... Read morePatient Care
view channel
Portable Biosensor Platform to Reduce Hospital-Acquired Infections
Approximately 4 million patients in the European Union acquire healthcare-associated infections (HAIs) or nosocomial infections each year, with around 37,000 deaths directly resulting from these infections,... Read more
First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds
Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more
Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization
An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more
Game-Changing Innovation in Surgical Instrument Sterilization Significantly Improves OR Throughput
A groundbreaking innovation enables hospitals to significantly improve instrument processing time and throughput in operating rooms (ORs) and sterile processing departments. Turbett Surgical, Inc.... Read moreHealth IT
view channel
Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors
The future of medicine is likely to focus on the personalization of healthcare—understanding exactly what an individual requires and delivering the appropriate combination of nutrients, metabolites, and... Read more
Smartwatches Could Detect Congestive Heart Failure
Diagnosing congestive heart failure (CHF) typically requires expensive and time-consuming imaging techniques like echocardiography, also known as cardiac ultrasound. Previously, detecting CHF by analyzing... Read morePoint of Care
view channel
Handheld, Sound-Based Diagnostic System Delivers Bedside Blood Test Results in An Hour
Patients who go to a doctor for a blood test often have to contend with a needle and syringe, followed by a long wait—sometimes hours or even days—for lab results. Scientists have been working hard to... Read more
Smartphone-Enabled, Paper-Based Quantitative Diagnostic Platform Transforms POC Testing
Point-of-care diagnostics are crucial for public health, offering rapid, on-site testing that enables prompt diagnosis and treatment. This is especially valuable in remote or underserved regions where... Read moreBusiness
view channel
Becton Dickinson to Spin Out Biosciences and Diagnostic Solutions Business
Becton, Dickinson and Company (BD, Franklin Lakes, NJ, USA), has announced that its board of directors has unanimously authorized BD management to pursue a plan to separate BD's Biosciences and Diagnostic... Read more