Static Magnetic Fields Enhance Bone Remodeling
By HospiMedica International staff writers Posted on 13 Mar 2019 |
Image: A new study claims static magnetic fields can increase stem cell osteogenic potential (Photo courtesy of the Chinese Academy of Medical Sciences).
Incorporating a static magnetic field (SMF) into 3D-printed (3DP) porous titanium scaffolds can help unleash the osteogenic potential of human bone-derived mesenchymal stem cells (hBMSCs), according to a new study.
Researchers at the Chinese Academy of Medical Sciences (Beijing), Peking Union Medical College Hospital (PUMCH; China), and other institutions used both hBMSCs and animal models to study the effects of SMF on bone growth. After seeding hBMSCs onto the surfaces of 3DP scaffolds, they divided the cell cultures into four groups, exposing them to different SMF strengths--O, 50, 100, and 150 milliTesla (mT)--for 14 days. Bone formation was significantly stronger among the SMF-treated cells, with the groups exposed to moderate levels of SMF (100 and 150 mT) performing better than those exposed to 0 (control) or 50 mT.
In a second, in-vivo experiment, the researchers used a rat model with a bone defect. After separating the rats into two groups, with the first as the control, the researchers exposed the second group to a moderate level (100 mT) of SMF. After 12 weeks, the researchers observed more new bone formation in the SMF-exposed rats than the control group. Proteomic analysis showed that 185 differential proteins were involved in osteogenic differentiation of hBMSCs under SMF conditions. The study was published on February 14, 2019, in The FASEB Journal.
“The in vivo experiment showed that bone regeneration and osseointegration was enhanced by SMF in the rat model of bone defect,” concluded corresponding author Hai Wang, PhD, of the department of orthopedic surgery at PUMCH and the Chinese Academy of Medical Sciences. “The reconstruction of large bone defects resulting from trauma, tumors, and infections remains a significant challenge for orthopedic surgeons. When it comes to enhancing new bone formation, SMF presents a more feasible alternative to both bone grafts and pulsed electromagnetic fields.”
Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin (mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc). Adult somatic stem cells can be artificially grown and differentiated into specialized cell types with characteristics consistent with cells of various tissues.
Related Links:
Chinese Academy of Medical Sciences
Peking Union Medical College Hospital
Researchers at the Chinese Academy of Medical Sciences (Beijing), Peking Union Medical College Hospital (PUMCH; China), and other institutions used both hBMSCs and animal models to study the effects of SMF on bone growth. After seeding hBMSCs onto the surfaces of 3DP scaffolds, they divided the cell cultures into four groups, exposing them to different SMF strengths--O, 50, 100, and 150 milliTesla (mT)--for 14 days. Bone formation was significantly stronger among the SMF-treated cells, with the groups exposed to moderate levels of SMF (100 and 150 mT) performing better than those exposed to 0 (control) or 50 mT.
In a second, in-vivo experiment, the researchers used a rat model with a bone defect. After separating the rats into two groups, with the first as the control, the researchers exposed the second group to a moderate level (100 mT) of SMF. After 12 weeks, the researchers observed more new bone formation in the SMF-exposed rats than the control group. Proteomic analysis showed that 185 differential proteins were involved in osteogenic differentiation of hBMSCs under SMF conditions. The study was published on February 14, 2019, in The FASEB Journal.
“The in vivo experiment showed that bone regeneration and osseointegration was enhanced by SMF in the rat model of bone defect,” concluded corresponding author Hai Wang, PhD, of the department of orthopedic surgery at PUMCH and the Chinese Academy of Medical Sciences. “The reconstruction of large bone defects resulting from trauma, tumors, and infections remains a significant challenge for orthopedic surgeons. When it comes to enhancing new bone formation, SMF presents a more feasible alternative to both bone grafts and pulsed electromagnetic fields.”
Most adult stem cells are lineage-restricted (multipotent) and are generally referred to by their tissue origin (mesenchymal stem cell, adipose-derived stem cell, endothelial stem cell, etc). Adult somatic stem cells can be artificially grown and differentiated into specialized cell types with characteristics consistent with cells of various tissues.
Related Links:
Chinese Academy of Medical Sciences
Peking Union Medical College Hospital
Latest Surgical Techniques News
- First-Ever Contact Force Pulsed Field Ablation System to Transform Treatment of Ventricular Arrhythmias
- Caterpillar Robot with Built-In Steering System Crawls Easily Through Loops and Bends
- Tiny Wraparound Electronic Implants to Revolutionize Treatment of Spinal Cord Injuries
- Small, Implantable Cardiac Pump to Help Children Awaiting Heart Transplant
- Gastrointestinal Imaging Capsule a Game-Changer in Esophagus Surveillance and Treatment
- World’s Smallest Laser Probe for Brain Procedures Facilitates Ablation of Full Range of Targets
- Artificial Intelligence Broadens Diagnostic Abilities of Conventional Coronary Angiography
- AI-Powered Surgical Visualization Tool Supports Surgeons' Visual Recognition in Real Time
- Cutting-Edge Robotic Bronchial Endoscopic System Provides Prompt Intervention during Emergencies
- Handheld Device for Fluorescence-Guided Surgery a Game Changer for Removal of High-Grade Glioma Brain Tumors
- Porous Gel Sponge Facilitates Rapid Hemostasis and Wound Healing
- Novel Rigid Endoscope System Enables Deep Tissue Imaging During Surgery
- Robotic Nerve ‘Cuffs’ Could Treat Various Neurological Conditions
- Flexible Microdisplay Visualizes Brain Activity in Real-Time To Guide Neurosurgeons
- Next-Gen Computer Assisted Vacuum Thrombectomy Technology Rapidly Removes Blood Clots
- Hydrogel-Based Miniaturized Electric Generators to Power Biomedical Devices