Activated Gold Particles Help Ablate Prostate Tumors
By HospiMedica International staff writers Posted on 09 Sep 2019 |
Image: GSNs scintillating under NIR laser light (Photo courtesy of Nanospectra Biosciences).
Gold-silica nanoshell (GSN) particles that absorb near-infrared light (NIR) can induce photothermal ablation of prostate cancer, claims a new study.
Researchers at Nanospectra Biosciences (Nanospectra; Houston, TX, USA), the Icahn School of Medicine at Mount Sinai (New York, NY, USA), Rice University (Rice, Houston, TX, USA), and other institutions conducted a clinical trial to examine the use of ultrafocal photothermal ablation for cancerous tumors. For the study, they used the Nanospectra AuroLase Therapy system, a focal ablation modality that relies on laser excitation of GSN to selectively target and treat focal lesions.
The GSN particles were designed to absorb NIR at wavelengths of high tissue transparency, providing highly localized treatment of prostate cancer with substantially reduced risks of deleterious treatment-related side effects. The study included 16 men (58-79 years of age) diagnosed with low or intermediate risk localized prostate cancer. All were given intravenous (IV) GSN nanoparticles, underwent treatment, and had a multiparametric MRI of the prostate at 48-72 hours. Targeted fusion biopsies were taken at 3 and 12 months, and finally a 12 core systematic biopsy was done one year after therapy.
The results revealed that GSN-mediated focal laser ablation was successful in 87.5% of lesions treated at one year of follow-up. The treatment protocol was found to be safe and feasible, and did not affect the genitourinary system of the patients. In addition, the patients’ quality of life (QOL) was preserved by reducing unwanted side effects, including erectile dysfunction and/or urine leakage, and there were no serious complications. The study was published on August 26, 2019, in Proceedings of National Academy of Science (PNAS).
Intravenously delivered GSNs preferentially accumulate within solid tumor tissue due to vessel wall fenestrations associated with aberrant tumor neovasculature and inherently defective lymphatic drainage within these lesions. On illumination with a NIR laser at subablative power, healthy tissue with lower concentrations of GSN suffers mild and reversible hyperthermia, while the higher concentrations of GSN within the cancerous lesion generate sufficient photothermal energy to produce coagulative necrosis.
Related Links:
Nanospectra Biosciences
Icahn School of Medicine at Mount Sinai
Rice University
Researchers at Nanospectra Biosciences (Nanospectra; Houston, TX, USA), the Icahn School of Medicine at Mount Sinai (New York, NY, USA), Rice University (Rice, Houston, TX, USA), and other institutions conducted a clinical trial to examine the use of ultrafocal photothermal ablation for cancerous tumors. For the study, they used the Nanospectra AuroLase Therapy system, a focal ablation modality that relies on laser excitation of GSN to selectively target and treat focal lesions.
The GSN particles were designed to absorb NIR at wavelengths of high tissue transparency, providing highly localized treatment of prostate cancer with substantially reduced risks of deleterious treatment-related side effects. The study included 16 men (58-79 years of age) diagnosed with low or intermediate risk localized prostate cancer. All were given intravenous (IV) GSN nanoparticles, underwent treatment, and had a multiparametric MRI of the prostate at 48-72 hours. Targeted fusion biopsies were taken at 3 and 12 months, and finally a 12 core systematic biopsy was done one year after therapy.
The results revealed that GSN-mediated focal laser ablation was successful in 87.5% of lesions treated at one year of follow-up. The treatment protocol was found to be safe and feasible, and did not affect the genitourinary system of the patients. In addition, the patients’ quality of life (QOL) was preserved by reducing unwanted side effects, including erectile dysfunction and/or urine leakage, and there were no serious complications. The study was published on August 26, 2019, in Proceedings of National Academy of Science (PNAS).
Intravenously delivered GSNs preferentially accumulate within solid tumor tissue due to vessel wall fenestrations associated with aberrant tumor neovasculature and inherently defective lymphatic drainage within these lesions. On illumination with a NIR laser at subablative power, healthy tissue with lower concentrations of GSN suffers mild and reversible hyperthermia, while the higher concentrations of GSN within the cancerous lesion generate sufficient photothermal energy to produce coagulative necrosis.
Related Links:
Nanospectra Biosciences
Icahn School of Medicine at Mount Sinai
Rice University
Latest Surgical Techniques News
- Tiny Wraparound Electronic Implants to Revolutionize Treatment of Spinal Cord Injuries
- Small, Implantable Cardiac Pump to Help Children Awaiting Heart Transplant
- Gastrointestinal Imaging Capsule a Game-Changer in Esophagus Surveillance and Treatment
- World’s Smallest Laser Probe for Brain Procedures Facilitates Ablation of Full Range of Targets
- Artificial Intelligence Broadens Diagnostic Abilities of Conventional Coronary Angiography
- AI-Powered Surgical Visualization Tool Supports Surgeons' Visual Recognition in Real Time
- Cutting-Edge Robotic Bronchial Endoscopic System Provides Prompt Intervention during Emergencies
- Handheld Device for Fluorescence-Guided Surgery a Game Changer for Removal of High-Grade Glioma Brain Tumors
- Porous Gel Sponge Facilitates Rapid Hemostasis and Wound Healing
- Novel Rigid Endoscope System Enables Deep Tissue Imaging During Surgery
- Robotic Nerve ‘Cuffs’ Could Treat Various Neurological Conditions
- Flexible Microdisplay Visualizes Brain Activity in Real-Time To Guide Neurosurgeons
- Next-Gen Computer Assisted Vacuum Thrombectomy Technology Rapidly Removes Blood Clots
- Hydrogel-Based Miniaturized Electric Generators to Power Biomedical Devices
- Custom 3D-Printed Orthopedic Implants Transform Joint Replacement Surgery
- Wearable Technology Monitors and Analyzes Surgeons' Posture during Long Surgical Procedures