Yarn Made from Human Tissue Helps Repair Wounds
By HospiMedica International staff writers Posted on 27 Feb 2020 |
Image: A spool of yarn made from extracellular matrix sheets (Photo courtesy of Nicolas L`Heureux/ INSERM)
Yarn grown from human skin cells can be knitted, crocheted, and sewed to create pouches, valves, and tubes, and even perforated membranes, according to a new study.
Developed by researchers at the French National Institute of Health and Medical Research (INSERM; Bordeaux, France), Fountain Therapeutics (Culver City, CA, USA), and other institutions, the “human textile” is made of cell-assembled extracellular matrix (CAM) sheets extracted from cultured adult, human fibroblasts. The biological, yet robust, material can be spun into a mass-produced yarn with a range of physical and mechanical properties for use in a range of clinical applications.
In the study, the researchers showed that the material can be used as a simple suture to close a wound, or even nitted into fully biological, human, implantable tissue-engineered vascular grafts (TEVGs) with mechanical burst pressure, suture retention strength, and transmural permeability that surpass clinical requirements. The yarn was also used to stitch up a rat’s wound, with the wound healing fully over the course of two weeks. IN addition, the researchers created a skin graft, using a custom-designed loom, to successfully stop a sheep’s artery from leaking. The study was published on January 26, 2020, in Acta Biomaterialia.
“By combining this truly ‘bio’ material with a textile-based assembly, this original tissue engineering approach is highly versatile and can produce a variety of strong human textiles that can be readily integrated in the body,” concluded senior author Nicolas L'Heureux, PhD, of INSERM, and colleagues. “This novel strategy holds the promise of a next generation of medical textiles that will be mechanically strong without any foreign scaffolding, and will have the ability to truly integrate into the host's body.”
The ECM is a collection of extracellular molecules that provides structural and biochemical support to the surrounding cells. It includes the interstitial matrix, composed of polysaccharide gels and fibrous proteins, and the basement membrane, which are sheet-like depositions on which various epithelial cells rest. Each type of connective tissue in animals has a different ECM; collagen fibers and bone mineral comprise the ECM of bone tissue; reticular fibers and ground substance comprise the ECM of loose connective tissue; and blood plasma is the ECM of blood.
Related Links:
French National Institute of Health and Medical Research
Fountain Therapeutics
Developed by researchers at the French National Institute of Health and Medical Research (INSERM; Bordeaux, France), Fountain Therapeutics (Culver City, CA, USA), and other institutions, the “human textile” is made of cell-assembled extracellular matrix (CAM) sheets extracted from cultured adult, human fibroblasts. The biological, yet robust, material can be spun into a mass-produced yarn with a range of physical and mechanical properties for use in a range of clinical applications.
In the study, the researchers showed that the material can be used as a simple suture to close a wound, or even nitted into fully biological, human, implantable tissue-engineered vascular grafts (TEVGs) with mechanical burst pressure, suture retention strength, and transmural permeability that surpass clinical requirements. The yarn was also used to stitch up a rat’s wound, with the wound healing fully over the course of two weeks. IN addition, the researchers created a skin graft, using a custom-designed loom, to successfully stop a sheep’s artery from leaking. The study was published on January 26, 2020, in Acta Biomaterialia.
“By combining this truly ‘bio’ material with a textile-based assembly, this original tissue engineering approach is highly versatile and can produce a variety of strong human textiles that can be readily integrated in the body,” concluded senior author Nicolas L'Heureux, PhD, of INSERM, and colleagues. “This novel strategy holds the promise of a next generation of medical textiles that will be mechanically strong without any foreign scaffolding, and will have the ability to truly integrate into the host's body.”
The ECM is a collection of extracellular molecules that provides structural and biochemical support to the surrounding cells. It includes the interstitial matrix, composed of polysaccharide gels and fibrous proteins, and the basement membrane, which are sheet-like depositions on which various epithelial cells rest. Each type of connective tissue in animals has a different ECM; collagen fibers and bone mineral comprise the ECM of bone tissue; reticular fibers and ground substance comprise the ECM of loose connective tissue; and blood plasma is the ECM of blood.
Related Links:
French National Institute of Health and Medical Research
Fountain Therapeutics
Latest Surgical Techniques News
- Miniaturized Implantable Multi-Sensors Device to Monitor Vessels Health
- Tiny Robots Made Out Of Carbon Could Conduct Colonoscopy, Pelvic Exam or Blood Test
- Miniaturized Ultrasonic Scalpel Enables Faster and Safer Robotic-Assisted Surgery
- AI Assisted Reading Tool for Small Bowel Video Capsule Endoscopy Detects More Lesions
- First-Ever Contact Force Pulsed Field Ablation System to Transform Treatment of Ventricular Arrhythmias
- Caterpillar Robot with Built-In Steering System Crawls Easily Through Loops and Bends
- Tiny Wraparound Electronic Implants to Revolutionize Treatment of Spinal Cord Injuries
- Small, Implantable Cardiac Pump to Help Children Awaiting Heart Transplant
- Gastrointestinal Imaging Capsule a Game-Changer in Esophagus Surveillance and Treatment
- World’s Smallest Laser Probe for Brain Procedures Facilitates Ablation of Full Range of Targets
- Artificial Intelligence Broadens Diagnostic Abilities of Conventional Coronary Angiography
- AI-Powered Surgical Visualization Tool Supports Surgeons' Visual Recognition in Real Time
- Cutting-Edge Robotic Bronchial Endoscopic System Provides Prompt Intervention during Emergencies
- Handheld Device for Fluorescence-Guided Surgery a Game Changer for Removal of High-Grade Glioma Brain Tumors
- Porous Gel Sponge Facilitates Rapid Hemostasis and Wound Healing
- Novel Rigid Endoscope System Enables Deep Tissue Imaging During Surgery