Suboptimal Weight Affects Survival in Cervical Cancer
|
By HospiMedica International staff writers Posted on 05 May 2016 |
|
Both overweight and underweight women with cervical cancer did not live as long as their normal-weight counterparts, according to a new study.
Researchers at the University of Cincinnati (OH, USA) and the University of North Carolina (UNC; Chapel Hill, USA) conducted a retrospective cohort study of 623 women with cervical cancer treated from July 2000 to March 2013, classifying the women according to their body mass index (BMI). In all, 4% of the women were underweight, 30% were normal weight, and 66% were overweight or obese. The primary outcome was overall survival; secondary outcomes included stage, histopathology, disease-specific survival (DSS), and recurrence free survival (RFS).
The results showed that the median overall survival time in overweight or obese women was six months shorter than in women of normal weight (22 versus 28 months); for underweight women, median overall survival time was cut in half (14 versus 28 months). There was no difference in age, stage at presentation, grade, or histology between weight categories. After controlling for prognostic factors, underweight and overweight/obese patients had worse median RFS than normal weight patients. The study was published on April 14, 2016, in in Gynecologic Oncology.
“In understanding the effect of BMI on cervical cancer outcomes, it is important to recognize that both extremes of weight appear to negatively impact survival. A potential unifying hypothesis connecting both extremes of weight to poor cancer prognosis is chronic systemic inflammation,” wrote lead author Leslie Clark, MD, of UNC, and colleagues. “Both patients with cancer cachexia/sarcopenia and overweight/obese patients are in a heightened inflammatory state, which may lead to increased cell proliferation and inhibition of apoptosis.”
"However, this is likely not the only mechanism of poor outcomes. Co-morbid medical conditions might account for some of the differences in survival, particularly in morbidly obese patients,” concluded the authors. “Providers should optimize weight in underweight and overweight/obese patients to attempt to improve outcomes in these women. Interventions that target nutritional counseling and physical activity should be explored in these populations.”
Related Links:
University of Cincinnati
University of North Carolina
Researchers at the University of Cincinnati (OH, USA) and the University of North Carolina (UNC; Chapel Hill, USA) conducted a retrospective cohort study of 623 women with cervical cancer treated from July 2000 to March 2013, classifying the women according to their body mass index (BMI). In all, 4% of the women were underweight, 30% were normal weight, and 66% were overweight or obese. The primary outcome was overall survival; secondary outcomes included stage, histopathology, disease-specific survival (DSS), and recurrence free survival (RFS).
The results showed that the median overall survival time in overweight or obese women was six months shorter than in women of normal weight (22 versus 28 months); for underweight women, median overall survival time was cut in half (14 versus 28 months). There was no difference in age, stage at presentation, grade, or histology between weight categories. After controlling for prognostic factors, underweight and overweight/obese patients had worse median RFS than normal weight patients. The study was published on April 14, 2016, in in Gynecologic Oncology.
“In understanding the effect of BMI on cervical cancer outcomes, it is important to recognize that both extremes of weight appear to negatively impact survival. A potential unifying hypothesis connecting both extremes of weight to poor cancer prognosis is chronic systemic inflammation,” wrote lead author Leslie Clark, MD, of UNC, and colleagues. “Both patients with cancer cachexia/sarcopenia and overweight/obese patients are in a heightened inflammatory state, which may lead to increased cell proliferation and inhibition of apoptosis.”
"However, this is likely not the only mechanism of poor outcomes. Co-morbid medical conditions might account for some of the differences in survival, particularly in morbidly obese patients,” concluded the authors. “Providers should optimize weight in underweight and overweight/obese patients to attempt to improve outcomes in these women. Interventions that target nutritional counseling and physical activity should be explored in these populations.”
Related Links:
University of Cincinnati
University of North Carolina
Gold Member
SARS‑CoV‑2/Flu A/Flu B/RSV Sample-To-Answer Test
SARS‑CoV‑2/Flu A/Flu B/RSV Cartridge (CE-IVD)
Gold Member
POC Blood Gas Analyzer
Stat Profile Prime Plus
New
Needle-Free IV Connector Technology
Clave
New
Lockable Drug Cabinet
MR2530
Latest Patient Care News
- Portable Biosensor Platform to Reduce Hospital-Acquired Infections
- First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds
- Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization
- Game-Changing Innovation in Surgical Instrument Sterilization Significantly Improves OR Throughput
- Next Gen ICU Bed to Help Address Complex Critical Care Needs
- Groundbreaking AI-Powered UV-C Disinfection Technology Redefines Infection Control Landscape
- Clean Hospitals Can Reduce Antibiotic Resistance, Save Lives
- Smart Hospital Beds Improve Accuracy of Medical Diagnosis
- New Fast Endoscope Drying System Improves Productivity and Traceability
- World’s First Automated Endoscope Cleaner Fights Antimicrobial Resistance
- Portable High-Capacity Digital Stretcher Scales Provide Precision Weighing for Patients in ER
- Portable Clinical Scale with Remote Indicator Allows for Flexible Patient Weighing Use
- Innovative and Highly Customizable Medical Carts Offer Unlimited Configuration Possibilities
- Biomolecular Wound Healing Film Adheres to Sensitive Tissue and Releases Active Ingredients
- Wearable Health Tech Could Measure Gases Released From Skin to Monitor Metabolic Diseases
- Wearable Cardioverter Defibrillator System Protects Patients at Risk of Sudden Cardiac Arrest
Channels
Critical Care
view channel
Breakthrough AI Technology Accurately Assesses Heart Failure Severity
Heart failure (HF) is a complex condition where the heart cannot effectively pump blood to meet the body’s needs due to underlying medical issues. It is marked by recurring episodes and frequent hospitalizations.... Read more
New Approach to Visualizing Blood Pressure Data Can Help Better Manage Hypertension Patients
Sometimes, a patient’s blood pressure may be elevated in a doctor's office but normal at home, a phenomenon known as white coat hypertension. It is estimated that 10% to 20% of high blood pressure diagnoses... Read more
Surgical Techniques
view channel
DNA Origami Improves Imaging of Dense Pancreatic Tissue for Cancer Detection and Treatment
One of the challenges of fighting pancreatic cancer is finding ways to penetrate the organ’s dense tissue to define the margins between malignant and normal tissue. Now, a new study uses DNA origami structures... Read more
Pioneering Sutureless Coronary Bypass Technology to Eliminate Open-Chest Procedures
In patients with coronary artery disease, certain blood vessels may be narrowed or blocked, requiring a stent or a bypass (also known as diversion) to restore blood flow to the heart. Bypass surgeries... Read more
Intravascular Imaging for Guiding Stent Implantation Ensures Safer Stenting Procedures
Patients diagnosed with coronary artery disease, which is caused by plaque accumulation within the arteries leading to chest pain, shortness of breath, and potential heart attacks, frequently undergo percutaneous... Read more
World's First AI Surgical Guidance Platform Allows Surgeons to Measure Success in Real-Time
Surgeons have always faced challenges in measuring their progress toward surgical goals during procedures. Traditionally, obtaining measurements required stepping out of the sterile environment to perform... Read moreHealth IT
view channel
Printable Molecule-Selective Nanoparticles Enable Mass Production of Wearable Biosensors
The future of medicine is likely to focus on the personalization of healthcare—understanding exactly what an individual requires and delivering the appropriate combination of nutrients, metabolites, and... Read more
Smartwatches Could Detect Congestive Heart Failure
Diagnosing congestive heart failure (CHF) typically requires expensive and time-consuming imaging techniques like echocardiography, also known as cardiac ultrasound. Previously, detecting CHF by analyzing... Read more
Business
view channel
Expanded Collaboration to Transform OR Technology Through AI and Automation
The expansion of an existing collaboration between three leading companies aims to develop artificial intelligence (AI)-driven solutions for smart operating rooms with sophisticated monitoring and automation.... Read more
