Bispecific Antibody Neutralizes Both Omicron and Delta Variants of SARS-CoV-2 in Studies with Live Virus
|
By HospiMedica International staff writers Posted on 07 Jan 2022 |
|
Illustration
An innovative bispecific antibody has been found to bind to and neutralize the Omicron and Delta variants of SARS-CoV-2 in live virus studies.
RBT-0813, a VHH bispecific antibody discovered by Revelar Biotherapeutics (Bethesda, MD, USA) and Twist Bioscience (South San Francisco, CA, USA), binds to the RBD (receptor binding domain) and appears to bind also outside of the RBM (receptor binding motif) of the SARS-CoV-2 spike protein, making it potentially less prone to escape mutations which are often concentrated in the RBM.
According to the new in vitro binding and neutralization data, binding and kinetic data were generated through Surface Plasmon Resonance (SPR) and independently confirmed by flow cytometry. The live virus plaque-reduction data were generated using live SARS-CoV-2 virus from ancestral, as well as the Omicron (B.1.1.529/BA.1) and Delta (B.1.617.2) variants of concern (VOC) isolated from patient nasopharyngeal specimens.
“With this data, we have now confirmed that RBT-0813 binds to and neutralizes both the Delta and Omicron variants of concern in pre-clinical laboratory testing,” said Glenn Marina, CEO of Revelar Biotherapeutics. “We are working diligently to complete preclinical and CMC development to support an IND and the initiation of clinical studies in humans. In parallel, we are in discussions with the U.S. Food and Drug Administration and expect to submit our IND in 1H2022.”
“We are encouraged by these positive results, building on data from peer-reviewed publications in Science and a recent publication in mAbs, that demonstrated Twist Biopharma’s ability to discover the individual antibodies used to build the bispecific RBT-0813,” said Emily M. Leproust, Ph.D., Chief Executive Officer and Co-Founder of Twist said. “These new results indicate that RBT-0813 could potentially offer treatment for patients infected with the most prevalent strains of COVID-19.”
Related Links:
Revelar Biotherapeutics
Twist Bioscience
Gold Member
Real-Time Diagnostics Onscreen Viewer
GEMweb Live
Gold Member
STI Test
Vivalytic Sexually Transmitted Infection (STI) Array
Silver Member
Wireless Mobile ECG Recorder
NR-1207-3/NR-1207-E
New
Ultra Low Floor Level Bed
Solite Pro
Latest COVID-19 News
- Low-Cost System Detects SARS-CoV-2 Virus in Hospital Air Using High-Tech Bubbles
- World's First Inhalable COVID-19 Vaccine Approved in China
- COVID-19 Vaccine Patch Fights SARS-CoV-2 Variants Better than Needles
- Blood Viscosity Testing Can Predict Risk of Death in Hospitalized COVID-19 Patients
- ‘Covid Computer’ Uses AI to Detect COVID-19 from Chest CT Scans
- MRI Lung-Imaging Technique Shows Cause of Long-COVID Symptoms
- Chest CT Scans of COVID-19 Patients Could Help Distinguish Between SARS-CoV-2 Variants
- Specialized MRI Detects Lung Abnormalities in Non-Hospitalized Long COVID Patients
- AI Algorithm Identifies Hospitalized Patients at Highest Risk of Dying From COVID-19
- Sweat Sensor Detects Key Biomarkers That Provide Early Warning of COVID-19 and Flu
- Study Assesses Impact of COVID-19 on Ventilation/Perfusion Scintigraphy
- CT Imaging Study Finds Vaccination Reduces Risk of COVID-19 Associated Pulmonary Embolism
- Third Day in Hospital a ‘Tipping Point’ in Severity of COVID-19 Pneumonia
- Longer Interval Between COVID-19 Vaccines Generates Up to Nine Times as Many Antibodies
- AI Model for Monitoring COVID-19 Predicts Mortality Within First 30 Days of Admission
- AI Predicts COVID Prognosis at Near-Expert Level Based Off CT Scans
Channels
Artificial Intelligence
view channel
AI-Powered Algorithm to Revolutionize Detection of Atrial Fibrillation
Atrial fibrillation (AFib), a condition characterized by an irregular and often rapid heart rate, is linked to increased risks of stroke and heart failure. This is because the irregular heartbeat in AFib... Read more
AI Diagnostic Tool Accurately Detects Valvular Disorders Often Missed by Doctors
Doctors generally use stethoscopes to listen for the characteristic lub-dub sounds made by heart valves opening and closing. They also listen for less prominent sounds that indicate problems with these valves.... Read more
Critical Care
view channel
AI Can Prioritize Emergecny Department Patients Requiring Urgent Treatment
Emergency departments across the world are facing severe overcrowding and excessive demands, but a new study indicates that artificial intelligence (AI) might soon assist in prioritizing patients who require... Read more
AI to Improve Diagnosis of Atrial Fibrillation
Abnormal heart rhythms frequently arise from—and contribute to—structural abnormalities in the heart. Atrial fibrillation is a specific type of abnormal rhythm that may not be consistently present, often... Read more
Stretchable Microneedles to Help In Accurate Tracking of Abnormalities and Identifying Rapid Treatment
The field of personalized medicine is transforming rapidly, with advancements like wearable devices and home testing kits making it increasingly easy to monitor a wide range of health metrics, from heart... Read more
Machine Learning Tool Identifies Rare, Undiagnosed Immune Disorders from Patient EHRs
Patients suffering from rare diseases often endure extensive delays in receiving accurate diagnoses and treatments, which can lead to unnecessary tests, worsening health, psychological strain, and significant... Read moreSurgical Techniques
view channel
Caterpillar Robot with Built-In Steering System Crawls Easily Through Loops and Bends
Soft robots often face challenges in being guided effectively because adding steering mechanisms typically reduces their flexibility by increasing rigidity. Now, a team of engineers has combined ancient... Read more
Tiny Wraparound Electronic Implants to Revolutionize Treatment of Spinal Cord Injuries
The spinal cord functions as a vital conduit, transmitting nerve impulses to and from the brain, much like a highway. When the spinal cord is damaged, this flow of information is disrupted, leading to... Read more
Small, Implantable Cardiac Pump to Help Children Awaiting Heart Transplant
Implantable ventricular assist devices, available for adults for over 40 years, fit inside the chest and are generally safer and easier to use than external devices. These devices enable patients to live... Read more
Gastrointestinal Imaging Capsule a Game-Changer in Esophagus Surveillance and Treatment
A newly-developed gastrointestinal imaging capsule is poised to be a game-changer in esophagus surveillance and interventions. The Multifunctional Ablative Gastrointestinal Imaging Capsule (MAGIC) developed... Read morePatient Care
view channel
First-Of-Its-Kind Portable Germicidal Light Technology Disinfects High-Touch Clinical Surfaces in Seconds
Reducing healthcare-acquired infections (HAIs) remains a pressing issue within global healthcare systems. In the United States alone, 1.7 million patients contract HAIs annually, leading to approximately... Read more
Surgical Capacity Optimization Solution Helps Hospitals Boost OR Utilization
An innovative solution has the capability to transform surgical capacity utilization by targeting the root cause of surgical block time inefficiencies. Fujitsu Limited’s (Tokyo, Japan) Surgical Capacity... Read more
Game-Changing Innovation in Surgical Instrument Sterilization Significantly Improves OR Throughput
A groundbreaking innovation enables hospitals to significantly improve instrument processing time and throughput in operating rooms (ORs) and sterile processing departments. Turbett Surgical, Inc.... Read more
Health IT
view channel
Machine Learning Model Improves Mortality Risk Prediction for Cardiac Surgery Patients
Machine learning algorithms have been deployed to create predictive models in various medical fields, with some demonstrating improved outcomes compared to their standard-of-care counterparts.... Read more
Strategic Collaboration to Develop and Integrate Generative AI into Healthcare
Top industry experts have underscored the immediate requirement for healthcare systems and hospitals to respond to severe cost and margin pressures. Close to half of U.S. hospitals ended 2022 in the red... Read more
AI-Enabled Operating Rooms Solution Helps Hospitals Maximize Utilization and Unlock Capacity
For healthcare organizations, optimizing operating room (OR) utilization during prime time hours is a complex challenge. Surgeons and clinics face difficulties in finding available slots for booking cases,... Read more
AI Predicts Pancreatic Cancer Three Years before Diagnosis from Patients’ Medical Records
Screening for common cancers like breast, cervix, and prostate cancer relies on relatively simple and highly effective techniques, such as mammograms, Pap smears, and blood tests. These methods have revolutionized... Read morePoint of Care
view channel
Critical Bleeding Management System to Help Hospitals Further Standardize Viscoelastic Testing
Surgical procedures are often accompanied by significant blood loss and the subsequent high likelihood of the need for allogeneic blood transfusions. These transfusions, while critical, are linked to various... Read more
Point of Care HIV Test Enables Early Infection Diagnosis for Infants
Early diagnosis and initiation of treatment are crucial for the survival of infants infected with HIV (human immunodeficiency virus). Without treatment, approximately 50% of infants who acquire HIV during... Read more
Whole Blood Rapid Test Aids Assessment of Concussion at Patient's Bedside
In the United States annually, approximately five million individuals seek emergency department care for traumatic brain injuries (TBIs), yet over half of those suspecting a concussion may never get it checked.... Read more
New Generation Glucose Hospital Meter System Ensures Accurate, Interference-Free and Safe Use
A new generation glucose hospital meter system now comes with several features that make hospital glucose testing easier and more secure while continuing to offer accuracy, freedom from interference, and... Read moreBusiness
view channel
Johnson & Johnson Acquires Cardiovascular Medical Device Company Shockwave Medical
Johnson & Johnson (New Brunswick, N.J., USA) and Shockwave Medical (Santa Clara, CA, USA) have entered into a definitive agreement under which Johnson & Johnson will acquire all of Shockwave’s... Read more
